肿瘤坏死因子（TNF）和肿瘤坏死因子受体1（TNFR1）基因多态性并非墨西哥人群类风湿关节炎的风险因素。
Tumor necrosis factor (TNF) and TNFR1 polymorphisms are not risk factors for rheumatoid arthritis in a Mexican population.
作者信息
Cadena-Sandoval Daniel, Alemán-Ávila Isidro, Barbosa-Cobos Rosa Elda, Becerril-Mendoza Lizbeth Teresa, Fragoso José Manuel, Ramírez-Bello Julián
机构信息
Research Unit on Endocrine and Metabolic Diseases, Hospital Juarez of México, Av. Instituto Politécnico Nacional 5160, Gustavo A. Madero, Magdalena de las Salinas, 07760, Mexico City, Mexico.
Superior School of Medicine Postgraduate Program, National Polytechnic Institute, Mexico City, Mexico.
出版信息
Mol Biol Rep. 2018 Jun;45(3):227-232. doi: 10.1007/s11033-018-4155-2. Epub 2018 Feb 5.
Tumor necrosis factor (TNF) plays an important role in the pathogenesis of rheumatoid arthritis (RA). Different genetic variants including the TNF -308G/A polymorphism are associated with RA susceptibility. However, these findings have not been replicated in all populations. The aim of this study was to determine whether the TNF -1031T/C (rs1799964), -376G/A (rs1800750), -308G/A (rs1800629) -238G/A (rs361525), and TNFR1 -609G/T polymorphisms are associated with RA susceptibility in a sample of Mexican patients. Our study included 499 patients with RA and 492 healthy controls. The genotypes of the TNF polymorphisms were obtained using TaqMan assay. The genotype and allele frequencies of the TNF -1031T/C, -376G/A, -308G/A, -238G/A, and TNFR1 -609G/T polymorphisms were similar among RA cases versus healthy controls, and no association with RA susceptibility was identified. Our results suggest that the TNF -1031T/C, -376G/A, -308G/A, -238G/A, and TNFR1 -609G/T polymorphisms are not associated with RA susceptibility in a sample of Mexican patients.
肿瘤坏死因子（TNF）在类风湿关节炎（RA）的发病机制中起重要作用。包括TNF -308G/A多态性在内的不同基因变异与RA易感性相关。然而，这些发现并非在所有人群中都得到重复验证。本研究的目的是确定在一组墨西哥患者样本中，TNF -1031T/C（rs1799964）、-376G/A（rs1800750）、-308G/A（rs1800629）、-238G/A（rs361525）以及TNFR1 -609G/T多态性是否与RA易感性相关。我们的研究纳入了499例RA患者和492例健康对照。采用TaqMan分析法获得TNF多态性的基因型。RA病例与健康对照之间，TNF -1031T/C、-376G/A、-308G/A、-238G/A以及TNFR1 -609G/T多态性的基因型和等位基因频率相似，未发现与RA易感性存在关联。我们的结果表明，在一组墨西哥患者样本中，TNF -1031T/C、-376G/A、-308G/A、-238G/A以及TNFR1 -609G/T多态性与RA易感性无关。
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