卡累利阿共和国俄罗斯人群中TNF -238G>A基因多态性与类风湿关节炎发病风险的关联分析
Analysis of the Association of TNF -238G>A Gene Polymorphism with the Risk of Rheumatoid Arthritis Development in Russian Population in the Republic of Karelia.
作者信息
Malysheva I E, Topchieva L V, Balan O V, Marusenko I M, Barysheva O Yu, Kurbatova I V
机构信息
Laboratory of Genetics, Institute of Biology, Karelian Research Center of the Russian Academy of Sciences, Petrozavodsk, Republic of Karelia, Russia.
Department of Hospital Therapy, Petrozavodsk State University, Petrozavodsk, Republic of Karelia, Russia.
出版信息
Bull Exp Biol Med. 2018 Sep;165(5):674-677. doi: 10.1007/s10517-018-4239-y. Epub 2018 Sep 17.
We studied association of the TNF gene -238G>A polymorphism (rs361525) with the risk of rheumatoid arthritis development in the Russian population living in the Republic of Karelia. The influence of rs361525 on the development of rheumatoid arthritis was revealed: genetic predisposition to this disease is associated with the presence of GG genotype. The effect of the genotype on the polymorphic locus of -238G>A on TNF mRNA content was revealed. Increased content of transcripts of this gene is associated with the presence of A allele.
我们研究了肿瘤坏死因子（TNF）基因-238G>A多态性（rs361525）与居住在卡累利阿共和国的俄罗斯人群类风湿关节炎发病风险的关联。揭示了rs361525对类风湿关节炎发病的影响：该疾病的遗传易感性与GG基因型的存在有关。揭示了基因型对TNF基因-238G>A多态性位点上TNF mRNA含量的影响。该基因转录本含量的增加与A等位基因的存在有关。
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