College of Chemistry and Chemical Engineering, Central South University , Changsha 410083, P. R. China.
College of Chemistry and Materials Science, Guangxi Teachers Education University , Nanning 530001, Guangxi, P. R. China.
J Org Chem. 2018 Mar 2;83(5):2948-2953. doi: 10.1021/acs.joc.7b02865. Epub 2018 Feb 15.
An efficient and diastereoselective decarboxylative oxa-1,3-dipolar cycloaddition between 3-oxindoles and diverse amino acids is developed to access novel oxazolidine-dispirooxindole skeletons bearing vicinal quaternary carbon centers. This protocol features operational simplicity, a broad substrate scope, and good to excellent chemical yields and diastereoselectivities. In particular, minimal solvent (1 mL/10 mmol) and chromatography-free purification render this synthetic process more efficient and environmentally benign in the context of green chemistry.
发展了一种高效的、非对映选择性的 3-氧吲哚与各种氨基酸的脱羧基氧杂-1,3-偶极环加成反应，以获得新型含有毗邻季碳中心的恶唑烷二螺[吲哚啉-3,3'-氧吲哚]骨架。该方法具有操作简单、底物适用范围广、产率和非对映选择性好等优点。特别是，在绿色化学的背景下，这种合成方法使用的溶剂最少（1 mL/10 mmol），且无需进行色谱纯化，因此更加高效、环境友好。
