Lang P, Santelli G, Benarbia S, Moritz S, Charpentier B, Fries D
Presse Med. 1986 May 17;15(20):915-8.
Clometacin is an antalgic drug with a chemical structure very similar to that of indomethacin; it is widely used in France. We report evidence for a cell-mediated immune mechanism in the pathogenesis of clometacin-induced acute interstitial nephritis. In the interstitial infiltrate of a female patient presenting with this condition, T cells constituted 75% of the total lymphocyte population. Cytotoxic/suppressor T cells predominated over helper/inducer T cells with a ratio of two to one. IgA-secreting plasmocytes were also present (about 23% of the inflammatory infiltrate). Peripheral blood lymphocyte studies showed that pre-incubation of the patient's cells with clometacin resulted in an increased sensitivity to interleukin 2 and a positive syngeneic mixed lymphocyte culture. This study seems to be relevant to the pathogenesis of acute interstitial nephritis induced by nonsteroidal anti-inflammatory drugs.
氯灭酸是一种镇痛药物，其化学结构与吲哚美辛非常相似；它在法国被广泛使用。我们报告了氯灭酸诱导的急性间质性肾炎发病机制中细胞介导免疫机制的证据。在一名患有这种疾病的女性患者的间质浸润中，T细胞占淋巴细胞总数的75%。细胞毒性/抑制性T细胞比辅助/诱导性T细胞占优势，比例为二比一。分泌IgA的浆细胞也存在（约占炎性浸润的23%）。外周血淋巴细胞研究表明，患者的细胞与氯灭酸预孵育后，对白细胞介素2的敏感性增加，并且同基因混合淋巴细胞培养呈阳性。这项研究似乎与非甾体抗炎药诱导的急性间质性肾炎的发病机制相关。
