Stachura I, Jayakumar S, Bourke E
Am J Med. 1983 Jul;75(1):9-16. doi: 10.1016/0002-9343(83)91161-0.
Renal failure due to combined acute interstitial nephritis and minimal-change glomerulopathy is reported in two patients after fenoprofen therapy. In the interstitial infiltrates, T lymphocytes predominated over B lymphocytes in a ratio of four to one. The majority of B lymphocytes present were IgE-bearing cells. Among the T cells, the ratio of cytotoxic/suppressor cells to helper-inducer cells was three to one. Repeated renal biopsy in one patient after steroid-induced clinical remission demonstrated resolution of the inflammatory infiltrate and restoration of normal glomerular foot processes. The theoretic and practical implications of these findings are discussed.
两名患者在服用非诺洛芬后出现了因急性间质性肾炎和微小病变性肾小球病合并导致的肾衰竭。在间质浸润中，T淋巴细胞与B淋巴细胞的比例为4:1，T淋巴细胞占主导。存在的B淋巴细胞大多数是携带IgE的细胞。在T细胞中，细胞毒性/抑制性细胞与辅助/诱导性细胞的比例为3:1。一名患者在类固醇诱导的临床缓解后进行重复肾活检，结果显示炎症浸润消退，肾小球足突恢复正常。文中讨论了这些发现的理论和实际意义。
