Alexandre C, Chappard D, Vico L, Minaire P, Riffat G
Presse Med. 1986 May 17;15(20):923-7.
Weightlessness results in negative calcium balance which can only reflect a redistribution of calcium in the body: the loss of calcium in the faeces and/or urine is constant, but an increase in urinary hydroxyproline indicating bone collagen destruction is not always detectable; moreover, a slowing down of collagen maturation may be suspected. Bone analysis by histomorphometry in animals and by indirect, non-invasive methods in man shows a decrease in bone mass. However, this bone tissue atrophy might only reflect excessive ageing of the bone during weightlessness, as suggested by slow bone formation and lack of variation in bone resorption. Since the experimental results obtained in men and animals during simulated weightlessness on earth are not strictly identical with those observed in space- flights, their validity may be questioned. Additional studies (notably histomorphometric studies) are therefore required for a better knowledge, as well as prevention, of the problems raised by human life in space.
失重会导致负钙平衡，这只能反映体内钙的重新分布：粪便和/或尿液中的钙流失是恒定的，但尿羟脯氨酸增加表明骨胶原破坏并非总是可检测到；此外，可能怀疑胶原成熟减缓。通过动物组织形态计量学和人体间接非侵入性方法进行的骨分析显示骨量减少。然而，这种骨组织萎缩可能仅反映失重期间骨骼过度老化，这是由缓慢的骨形成和骨吸收缺乏变化所暗示的。由于在地球上模拟失重期间在人和动物身上获得的实验结果与在太空飞行中观察到的结果并不完全相同，其有效性可能受到质疑。因此，需要进行更多研究（尤其是组织形态计量学研究），以便更好地了解并预防太空人类生活所带来的问题。
