尼群地平、硝苯地平和维拉帕米可抑制体外不可逆镰状细胞的形成。

Nitrendipine, nifedipine and verapamil inhibit the in vitro formation of irreversibly sickled cells.

作者信息

Ohnishi S T, Horiuchi K Y, Horiuchi K, Jurman M E, Sadanaga K K

出版信息

Pharmacology. 1986;32(5):248-56. doi: 10.1159/000138177.

Abstract

Nitrendipine, nifedipine and verapamil inhibit the in vitro formation of irreversibly sickled cells. Using a method of forming both dehydrated cells and irreversibly sickled cells in vitro by repeated cycles of sickling and unsickling, the effects of several drugs in inhibiting the formation of these cells were studied. Drugs known as Ca2+ channel antagonists, such as nitrendipine, nifedipine and verapamil were found to inhibit these reactions. Other types of calcium channel blockers, such as lanthanum and zinc, did not inhibit the formation of these cells. The potency of drugs to inhibit irreversibly sickled cell formation was related to the potency of inhibition of calmodulin-activated phosphodiesterase.

摘要

尼群地平、硝苯地平和维拉帕米可抑制体外不可逆镰状细胞的形成。采用通过反复的镰状化和去镰状化循环在体外形成脱水细胞和不可逆镰状细胞的方法，研究了几种药物对这些细胞形成的抑制作用。发现被称为钙离子通道拮抗剂的药物，如尼群地平、硝苯地平和维拉帕米，可抑制这些反应。其他类型的钙通道阻滞剂，如镧和锌，并未抑制这些细胞的形成。药物抑制不可逆镰状细胞形成的效力与抑制钙调蛋白激活的磷酸二酯酶的效力相关。