Howard-Lock H E, Lock C J, Mewa A, Kean W F
Semin Arthritis Rheum. 1986 May;15(4):261-81. doi: 10.1016/0049-0172(86)90022-3.
The discovery of D-penicillamine and its uses in medicine are reviewed. Chemical-physical properties are discussed, and the molecular structure of D-penicillamine and several of its reaction products are illustrated. Examples of its three main types of biochemical reactions--sulfhydryl-disulfide exchange, thiazolidine formation, and metal chelation are included. Trials of D-penicillamine in RA patients are reviewed critically. The administration of the drug is discussed in detail, including dosages, clinical and laboratory responses, patterns of adverse side effects or toxicity, drug-induced autoimmune diseases, indications and contraindications, and the monitoring and management of patients.
本文综述了D-青霉胺的发现及其在医学中的应用。讨论了其化学物理性质，并阐述了D-青霉胺及其几种反应产物的分子结构。文中还列举了其三种主要生化反应的实例——巯基-二硫键交换、噻唑烷形成和金属螯合。对D-青霉胺在类风湿关节炎（RA）患者中的试验进行了严格审查。详细讨论了该药物的给药情况，包括剂量、临床和实验室反应、不良反应或毒性模式、药物诱导的自身免疫性疾病、适应证和禁忌证，以及患者的监测和管理。
