Joyce D A
Baillieres Clin Rheumatol. 1990 Dec;4(3):553-74. doi: 10.1016/s0950-3579(05)80007-x.
D-Pen represents an effective treatment for a proportion of patients with RA and PSS. Its status in the treatment of juvenile RA is uncertain. The best results will be obtained by a skillful, careful physician maintaining careful surveillance for toxicity. Neither the mode of action nor the mechanisms of toxicity are well understood in RA. Consequently, safer and more effective analogues of D-pen have not been produced.
青霉胺对一部分类风湿关节炎（RA）和硬皮病（PSS）患者而言是一种有效的治疗方法。其在幼年型类风湿关节炎治疗中的地位尚不确定。技艺娴熟、谨慎的医生进行仔细的毒性监测，将会取得最佳效果。在类风湿关节炎中，其作用方式和毒性机制都尚未完全明确。因此，尚未研制出更安全、更有效的青霉胺类似物。
