Department of Biofunctional Imaging, Preeminent Medical Photonics Education & Research Center, Hamamatsu University School of Medicine, Hamamatsu, Japan.
First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.
J Neurol Sci. 2018 Feb 15;385:30-33. doi: 10.1016/j.jns.2017.12.004. Epub 2017 Dec 6.
Chronic activation of microglia accelerates the neurodegenerative process in multiple sclerosis (MS). Although disease modifying therapy (DMT) is reportedly effective for neuroinflammatory responses in MS, the progression of neuroinflammation after DMT remains unclear.
We evaluated microglial activation in six clinically stable relapsing-remitting MS patients after DMT by quantifying changes in translocator protein (TSPO) density using PET with [C]DPA713, a selective TSPO tracer for microglial activation. All patients underwent [C]DPA713 PET scans twice, and the scans were conducted one year apart. The binding potential (BP) of the tracer was estimated using a simplified reference tissue model.
[C]DPA713 BP measured at 6months after DMT was significantly higher in the MS group than that in the control group. Compared with the first PET measurement, the one-year PET measurement revealed significantly elevated [C]DPA713 BP in broader brain regions covering the temporal and parietal cortices after one year of DMT.
The current results indicate that microglial activation may proceed in the entire brain of clinically stable MS patients even after receiving DMT.
小胶质细胞的慢性激活加速了多发性硬化症（MS）中的神经退行性过程。虽然据报道疾病修正治疗（DMT）对 MS 中的神经炎症反应有效，但 DMT 后神经炎症的进展仍不清楚。
我们通过使用 [C]DPA713 正电子发射断层扫描（PET）定量测量 TSPO 密度，评估了六名临床稳定的复发缓解型 MS 患者在 DMT 后的小胶质细胞激活情况，[C]DPA713 是一种用于小胶质细胞激活的选择性 TSPO 示踪剂。所有患者均进行了两次 [C]DPA713 PET 扫描，两次扫描相隔一年。使用简化的参考组织模型估计示踪剂的结合势（BP）。
DMT 后 6 个月时，MS 组的 [C]DPA713 BP 明显高于对照组。与第一次 PET 测量相比，一年后的 PET 测量显示，在 DMT 一年后，包括颞叶和顶叶皮层在内的更广泛脑区的 [C]DPA713 BP 显著升高。
目前的结果表明，即使在接受 DMT 后，临床稳定的 MS 患者的整个大脑中也可能存在小胶质细胞激活。
