帕金森病中小胶质细胞激活的纹状体外扩散：一项正电子发射断层扫描研究。
Extrastriatal spreading of microglial activation in Parkinson's disease: a positron emission tomography study.
作者信息
Terada Tatsuhiro, Yokokura Masamichi, Yoshikawa Etsuji, Futatsubashi Masami, Kono Satoshi, Konishi Takashi, Miyajima Hiroaki, Hashizume Takanori, Ouchi Yasuomi
机构信息
Department of Biofunctional Imaging, Medical Photonics Research Center, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, 431-3192, Japan.
Department of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan.
出版信息
Ann Nucl Med. 2016 Oct;30(8):579-87. doi: 10.1007/s12149-016-1099-2. Epub 2016 Jun 14.
BACKGROUND
The neuroinflammatory glial response contributes to the degenerative process in Parkinson's disease (PD). However, the pattern of microglial progression remains unclear.
METHODS
We evaluated microglial activation in early stage PD patients by quantifying changes in neuroinflammation using PET with [(11)C]DPA713, a selective PET tracer for microglial activation. Eleven PD patients (Hoehn and Yahr stages 1-2) without dementia underwent the [(11)C]DPA713 PET scan two times with 1 year apart. The binding potential (BPND) was estimated with the simplified reference tissue model. Voxelwise and regions of interest analyses were used to compare the regional BPND among groups.
RESULTS
Significant increase in [(11)C]DPA713 BPND was found extrastriatally in the occipital, temporal and parietal cortex in PD patients, and the degree of BPND became much higher over the brain regions predominantly in the temporal and occipital cortex 1 year later.
CONCLUSION
The current results indicated that an extrastriatal spreading of microglial activation reflects one of PD pathophysiology occurring at an early stage.
背景
神经炎性胶质细胞反应参与帕金森病（PD）的退行性变过程。然而，小胶质细胞进展模式仍不清楚。
方法
我们通过使用[(11)C]DPA713（一种用于小胶质细胞活化的选择性正电子发射断层扫描（PET）示踪剂）进行PET定量神经炎症变化，评估早期PD患者的小胶质细胞活化情况。11例无痴呆的PD患者（Hoehn和Yahr分期1-2期）相隔1年接受两次[(11)C]DPA713 PET扫描。用简化参考组织模型估计结合潜能（BPND）。采用体素分析和感兴趣区域分析比较各组间的区域BPND。
结果
在PD患者的枕叶、颞叶和顶叶皮质纹状体外区域发现[(11)C]DPA713 BPND显著增加，1年后在主要位于颞叶和枕叶皮质的脑区BPND程度变得更高。
结论
目前结果表明，小胶质细胞活化的纹状体外扩散反映了PD早期发生的病理生理学过程之一。
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