Department of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, Carl-Neuberg-Strasse 1, Hannover 30625, Germany; Department of Neurology, Hannover Medical School, Carl-Neuberg-Strasse 1, Hannover 30625, Germany.
Department of Neurology, Hannover Medical School, Carl-Neuberg-Strasse 1, Hannover 30625, Germany.
J Neurol Sci. 2018 Feb 15;385:7-11. doi: 10.1016/j.jns.2017.11.042. Epub 2017 Dec 1.
Lulé, Ludolph, and Ludolph (2008) hypothesized that there may be a pathophysiological link between attention-deficit/hyperactivity disorder (ADHD) and amyotrophic lateral sclerosis (ALS). They summarized common clinical features, specifically enhanced physical and psychological activity, which have been described typically for ADHD patients and also as common personality traits before disease onset in patients with ALS.
We assessed the lifetime prevalence rate of ADHD in 104 patients with ALS using valid self-report instruments for ADHD symptoms in childhood (WURS-k) and adulthood (ADHD-SB). Results were compared with a population-based sample (n=2069) and with patients with Parkinson's disease (PD, n=52) using regression analyses and adjusting for sociodemographic differences. Physical activity was assessed by the 21-item exercise dependency scale (EDS-21).
ALS patients reported a lower prevalence of childhood ADHD compared to the general population. Both clinical groups reported significantly lower scores on the WURS-k scale and the attention deficit subscale of the ADHD-SB. The EDS-21 showed significantly longer exercise times in ALS and PD patients.
We could not show that ADHD is more common in ALS patients. However, our results revealed shared personality traits in ALS and PD with lower rates of premorbid attention deficit symptoms and increased physical activity.
Lulé、Ludolph 和 Ludolph（2008 年）假设注意力缺陷多动障碍（ADHD）和肌萎缩侧索硬化症（ALS）之间可能存在病理生理学联系。他们总结了常见的临床特征，特别是增强的身体和心理活动，这些特征通常被描述为 ADHD 患者的特征，也被描述为 ALS 患者发病前的常见人格特征。
我们使用有效的 ADHD 症状自评量表（WURS-k）和成人 ADHD 自评量表（ADHD-SB）评估了 104 例 ALS 患者的终身 ADHD 患病率。结果与基于人群的样本（n=2069）和帕金森病（PD，n=52）患者进行了比较，使用回归分析并调整了社会人口统计学差异。身体活动通过 21 项运动依赖量表（EDS-21）进行评估。
与一般人群相比，ALS 患者报告的儿童期 ADHD 患病率较低。两个临床组在 WURS-k 量表和 ADHD-SB 的注意力缺陷分量表上的得分都明显较低。EDS-21 显示 ALS 和 PD 患者的运动时间明显更长。
我们不能证明 ADHD 在 ALS 患者中更为常见。然而，我们的结果揭示了 ALS 和 PD 之间存在共同的人格特征，即发病前注意力缺陷症状的发生率较低，身体活动增加。
