Department of Physiology, Medical School of Nanchang University, Nanchang 330006, PR China; Department of Chemistry, Nanchang University, Nanchang 330031, PR China.
Department of Chemistry, Nanchang University, Nanchang 330031, PR China.
Mater Sci Eng C Mater Biol Appl. 2018 Apr 1;85:233-238. doi: 10.1016/j.msec.2017.12.031. Epub 2018 Jan 3.
Supramolecular polymerization is a novel method for the fabrication of multifunctional polymeric composites that mainly relied on the non-covalent interactions between different components. In this work, a novel and facile strategy has been developed for the construction of fluorescent organic nanoparticles (FONs) with aggregation-induced emission (AIE) characteristic based on the host-guest interaction between β cyclodextrin terminating polyethylene glycol (β-CD-PEG) and adamantine (Ad) containing AIE dye (Ph-Ad). Through the host-guest interaction, the fluorescent amphiphiles can be facilely obtained. The characterization results suggested we have successfully prepared the AIE-active FONs through the supramolecular polymerization. The Ph-Ad/β-CD-PEG FONs possess many advantages such small size, high water dispersibility, desirable fluorescence properties, low cytotoxicity and efficient cell dyeing performance. All of the above results implied that these AIE-active supramolecular assemblies should be promising luminescent probes with great potential for different biomedical applications.
超分子聚合是一种制备多功能聚合复合材料的新方法，主要依赖于不同组分之间的非共价相互作用。在这项工作中，我们开发了一种新颖而简便的策略，基于β-环糊精封端的聚乙二醇（β-CD-PEG）与含有聚集诱导发射（AIE）特性的金刚烷（Ad）的主客体相互作用，构建具有聚集诱导发射（AIE）特性的荧光有机纳米粒子（FONs）。通过主客体相互作用，可以轻易获得荧光两亲物。表征结果表明，我们已经成功地通过超分子聚合制备了 AIE 活性的 FONs。Ph-Ad/β-CD-PEG FONs 具有许多优点，如尺寸小、高水分散性、理想的荧光性质、低细胞毒性和高效的细胞染色性能。所有这些结果表明，这些 AIE 活性的超分子组装体应该是具有很大潜力的用于不同生物医学应用的有前途的发光探针。
