Department of Environmental Health Engineering, Student Research Committee, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Environmental and Occupational Hazards Control Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Food Chem Toxicol. 2018 Mar;113:278-286. doi: 10.1016/j.fct.2018.01.046. Epub 2018 Jan 31.
The ingestion of heavy metals through contaminated seafood can causes significant outcomes on human health. In recent years, consume fishes and shrimps has increased in Iran, and several study about heavy metals content in fishes and shrimps from Persian Gulf were carried out to check their food safety. The aims of these systematic reviews and meta-analysis was to summarize the evidence on the relation of the intakes of Arsenic (As) and lead (Pb) levels, based on the origin and sub-groups of shrimp species consumed, Hence that we can estimate the risk of oral cancer induced by Pb and As in these groups of shrimp from the persian gulf. We carried out a search of all suitable studies published between 1995 and 2017 in Scopus, Science Direct, PubMed and Web of Science databases. Since the heterogeneity among studied was significant, we used the random effect model (REM) to perform meta-analysis of data. Data were obtained from 9 articles (14 studies), with 511 samples, and it was reported that pooled levels of As and Pb in the muscle shrimps were 1.37 (95% CI: 0.66-2.08 mg/kg d.w.) and 0.58 (95% CI: 0.33-0.82 mg/kg d.w.), respectively. This pooled levels in muscle shrimps were higher than safe dose reported on Food and Agriculture Organization/World Health Organization guidelines (FAO/WHO). The rank order of shrimps species based on As was Panulirus homarus > Penaeus semisulcatus and for the Pb levels was Litopenaeus vannamei > Panulirus homarus > Fenneropenaeus indicus > Metapenaeus affinis. The lowest and highest risk levels of oral cancer, divided by consumers age groups, were respectively 45-54 (6.94E-04) and 15-24 (8.42E-04) for the Pb, and 45-54 (2.87E-01) and 15-24 (3.51E-01) for arsenic. Incremental Lifetime Cancer Risk (ILCR) of Pb and As was higher than 10-4 and 10-3, respectively. All groups (age) of consumers are subject to the cancer risk of due to the consumption of shrimps contaminated by Pb and As, therefore, should be started a control plan for the reduction of the heavy metal bioaccumulation levels in shrimps of the Persian Gulf coupled to a capillary food safety communication.
通过受污染的海鲜摄入重金属会对人类健康造成重大影响。近年来，伊朗人食用鱼类和虾类的数量有所增加，因此对来自波斯湾的鱼类和虾类中的重金属含量进行了几项研究，以检查其食品安全。这些系统评价和荟萃分析的目的是总结砷 (As) 和铅 (Pb) 摄入量与虾类来源和亚群之间关系的证据，从而可以估计来自波斯湾的这些虾类组中铅和砷引起口腔癌的风险。我们在 Scopus、Science Direct、PubMed 和 Web of Science 数据库中搜索了 1995 年至 2017 年期间发表的所有合适的研究。由于研究之间的异质性非常显著，因此我们使用随机效应模型 (REM) 对数据进行荟萃分析。数据来自 9 篇文章（14 项研究），涉及 511 个样本，结果表明肌肉虾中砷和铅的浓度分别为 1.37（95%置信区间：0.66-2.08mg/kg 干重）和 0.58（95%置信区间：0.33-0.82mg/kg 干重）。肌肉虾中的这些浓度高于粮农组织/世界卫生组织准则（FAO/WHO）报告的安全剂量。根据砷含量对虾类进行的排序是 Homarus panulirus > Penaeus semisulcatus，而对于铅水平则是 Litopenaeus vannamei > Homarus panulirus > Fenneropenaeus indicus > Metapenaeus affinis。按消费者年龄组划分的口腔癌最低和最高风险水平分别为铅为 45-54 岁（6.94E-04）和 15-24 岁（8.42E-04），砷为 45-54 岁（2.87E-01）和 15-24 岁（3.51E-01）。铅和砷的增量终生癌症风险（ILCR）均高于 10-4 和 10-3。由于食用受铅和砷污染的虾类，所有年龄组（年龄）的消费者都面临癌症风险，因此应制定一项控制计划，以减少波斯湾虾类中的重金属生物累积水平，并结合毛细血管食品安全宣传。
