Vaxxinova GmbH, Deutscher Platz 5e, 04103 Leipzig, Germany.
Institute of Virology, Center for Infectious Diseases, Faculty of Veterinary Medicine, University of Leipzig, An den Tierkliniken 29, 04103 Leipzig, Germany.
Vet Microbiol. 2018 Feb;214:93-98. doi: 10.1016/j.vetmic.2017.12.014. Epub 2017 Dec 21.
Group A porcine rotaviruses are a global threat to animal health in stock breeding. While certain genotypes have shown predominance in other countries, data from Europe's second largest swine population is still scarce. Therefore, porcine rotaviruses taken from different areas of Germany were genotyped to create a basis for comparison with data from neighboring countries. In addition, the potential predominance and regionality based on regions (federal states) have been investigated by examining 101 samples. The study revealed the dominance of the VP7 genotypes G9, G4, G5 as well as VP4 genotypes P[23], P[6], P[32]. The most common genotype combinations were G9P[23], G4P[6], and G9P[32]. Analysis focusing on the regionality aspect revealed that areas with high pig populations promote the emergence of dominant genotype combinations. However, pig populations in Germany cannot be considered individually and therefore results were put into international context, taken from already published genotyping data. In consequence, our data contributes to the fundamental understanding of regional and supraregional rotavirus epidemiology. The detected genotypes provide a basis for prospective porcine rotavirus surveillance, that first of all helps to identify interspecies transmission. Furthermore it may provide supporting data for the selection of particular genotypes, suitable for the production of porcine rotavirus A vaccine candidates.
A 组猪轮状病毒是全球范围内对畜牧业动物健康的威胁。虽然某些基因型在其他国家占据主导地位，但欧洲第二大养猪群体的数据仍然稀缺。因此，对来自德国不同地区的猪轮状病毒进行了基因分型，为与邻国数据进行比较奠定了基础。此外，通过检查 101 个样本，研究了基于区域（联邦州）的潜在优势和地域性。研究表明，VP7 基因型 G9、G4、G5 以及 VP4 基因型 P[23]、P[6]、P[32]占据主导地位。最常见的基因型组合是 G9P[23]、G4P[6]和 G9P[32]。关注地域性方面的分析表明，猪群数量较高的地区促进了优势基因型组合的出现。然而，德国的猪群不能被单独考虑，因此结果被纳入国际背景，取自已发表的基因分型数据。因此，我们的数据有助于对区域性和超区域性轮状病毒流行病学的基本理解。检测到的基因型为前瞻性猪轮状病毒监测提供了基础，这首先有助于识别种间传播。此外，它还可以为选择适合生产猪轮状病毒 A 疫苗候选物的特定基因型提供支持数据。
