Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine, Nursing and Health Sciences, National University of Ireland, Galway, Ireland; CÚRAM Centre for Research in Medical Devices, National University of Ireland, Galway, Ireland.
Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine, Nursing and Health Sciences, National University of Ireland, Galway, Ireland; Discipline of Pharmacology and Therapeutics, College of Medicine, Nursing and Health Sciences, National University of Ireland, Galway, Ireland; CÚRAM Centre for Research in Medical Devices, National University of Ireland, Galway, Ireland.
Adv Drug Deliv Rev. 2018 Apr;129:394-406. doi: 10.1016/j.addr.2018.01.018. Epub 2018 Jan 31.
Impaired healing of cutaneous wounds and ulcers continues to have a major impact on the quality of life of millions of people. In recent years, the capacity for stem and progenitor cells to promote wound repair has been investigated with evidence that secreted factors are responsible for the observed therapeutic benefits. This review addresses current evidence in support of stem/progenitor cell-derived extracellular vesicles (EVs) as a regenerative therapy for acceleration of wound healing. Encouraging results for local or systemic administration of EVs have been reported in a range of clinically-relevant animal models of cutaneous wounds. Furthermore, a number of plausible mechanisms involving EV-mediated transfer of proteins and RNAs that trigger pro-repair pathways in target cells have been demonstrated experimentally. However, for successful clinical translation in the coming years, further emphasis on standardized experimental protocols, detailed methodological reporting and clear definition of EV-based therapeutic products will be required.
皮肤创伤和溃疡的愈合受损仍然对数百万人的生活质量产生重大影响。近年来，干细胞和祖细胞促进伤口修复的能力已经得到了研究，有证据表明分泌因子是观察到的治疗益处的原因。本综述介绍了支持干细胞/祖细胞衍生的细胞外囊泡（EVs）作为一种促进伤口愈合的再生治疗方法的现有证据。已经在一系列临床上相关的皮肤创伤动物模型中报告了局部或全身给予 EV 的令人鼓舞的结果。此外，实验已经证实了一些合理的机制，涉及 EV 介导的蛋白质和 RNA 的转移，这些蛋白质和 RNA 可以在靶细胞中触发促修复途径。然而，为了在未来几年成功进行临床转化，还需要进一步强调标准化的实验方案、详细的方法报告以及对基于 EV 的治疗产品的明确定义。
