Institute of Microsurgery on Extremities, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, People's Republic of China.
Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, People's Republic of China.
Stem Cells Transl Med. 2017 Sep;6(9):1753-1758. doi: 10.1002/sctm.16-0477. Epub 2017 Jun 27.
Stem cells, with their therapeutic potential in tissue repair and regeneration, have been widely used in translational medicine. Recent evidence suggests that the beneficial effects are mediated largely by their paracrine actions rather than the engraftment and differentiation at the injured sites. Extracellular vesicles (EVs), actively released from cells, play important roles in cell-to-cell communication and display multiple functions in tissue regeneration. In the present report, we will briefly review the current knowledge related to the therapeutic potential of EVs, particularly stem cell or progenitor cell-derived ones for promoting tissue repair and regeneration, and focus on the restorative properties of exosomes/microvesicles in cutaneous wound healing, bone regeneration, hindlimb ischemia, and vascular injury repair. Stem Cells Translational Medicine 2017;6:1753-1758.
干细胞具有组织修复和再生的治疗潜力，已广泛应用于转化医学。最近的证据表明，这些有益的影响主要是通过旁分泌作用介导的，而不是在损伤部位的植入和分化。细胞外囊泡（EVs）是细胞主动释放的，在细胞间通讯中发挥重要作用，并在组织再生中显示出多种功能。在本报告中，我们将简要回顾与 EVs 的治疗潜力相关的最新知识，特别是干细胞或祖细胞衍生的 EVs 在促进组织修复和再生方面的作用，并重点介绍外泌体/微泡在皮肤伤口愈合、骨再生、后肢缺血和血管损伤修复中的修复特性。《Stem Cells Translational Medicine》2017 年；6：1753-1758.
