对接受供体造血干细胞的 HLA 配型相同的肾移植配对患者进行耐受性方案的更新随访。
Updated follow-up of a tolerance protocol in HLA-identical renal transplant pairs given donor hematopoietic stem cells.
作者信息
Leventhal Joseph R, Miller Joshua, Mathew James M, Kurian Sunil, Tambur Anat R, Friedewald John, Charrette Jane, Abecassis Michael M
机构信息
Comprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL, USA.
Comprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL, USA; Department of Microbiology-Immunology, Northwestern University, Chicago, IL, USA.
出版信息
Hum Immunol. 2018 May;79(5):277-282. doi: 10.1016/j.humimm.2018.01.010. Epub 2018 Feb 1.
Abstract
Kidney transplant recipients given donor hematopoietic stem cells from their HLA-identical living related donors have now been followed between 5 and 9½ years post-operatively. Recipients who were designated as tolerant (Tol) have remained so since the last report when the 5 year (biopsy associated) milestone was reached. There has been 1 mortality of a Tol patient, unrelated to the study protocol, while 5 (of 15) have remained Tol between 7 and 8½ years post-operatively. There has been continuing elevated T-regulatory (CD4CD25CD127FOXP3) cells in PBMC previously reported on. Ten year renal transplant biopsies are tentatively planned.
摘要
接受来自 HLA 匹配的活体亲属供体的造血干细胞的肾移植受者，目前已在术后 5 至 9.5 年接受随访。自上次报告达到 5 年（活检相关）里程碑以来，被指定为耐受（Tol）的受者一直保持这种状态。有 1 例 Tol 患者死亡，与研究方案无关，而 15 例中有 5 例在术后 7 至 8.5 年仍保持 Tol 状态。之前报道的外周血单核细胞中调节性 T 细胞（CD4CD25CD127FOXP3）持续升高。初步计划进行 10 年肾移植活检。
相似文献
1
Updated follow-up of a tolerance protocol in HLA-identical renal transplant pairs given donor hematopoietic stem cells.对接受供体造血干细胞的 HLA 配型相同的肾移植配对患者进行耐受性方案的更新随访。
Hum Immunol. 2018 May;79(5):277-282. doi: 10.1016/j.humimm.2018.01.010. Epub 2018 Feb 1.
2
Nonchimeric HLA-Identical Renal Transplant Tolerance: Regulatory Immunophenotypic/Genomic Biomarkers.非嵌合型 HLA 相同的肾移植耐受性：调节性免疫表型/基因组生物标志物
Am J Transplant. 2016 Jan;16(1):221-34. doi: 10.1111/ajt.13416. Epub 2015 Jul 30.
3
4
Genomic biomarkers correlate with HLA-identical renal transplant tolerance.基因组生物标志物与 HLA 相同的肾移植耐受相关。
J Am Soc Nephrol. 2013 Sep;24(9):1376-85. doi: 10.1681/ASN.2013010068. Epub 2013 Jun 20.
5
Clinical strategy for induction of transplantation tolerance through mixed chimerism.通过混合嵌合体诱导移植耐受的临床策略。
Clin Transpl. 2013:127-34.
6
Immune reconstitution/immunocompetence in recipients of kidney plus hematopoietic stem/facilitating cell transplants.肾移植联合造血干细胞/辅助细胞移植受者的免疫重建/免疫能力
Transplantation. 2015 Feb;99(2):288-98. doi: 10.1097/TP.0000000000000605.
7
Successful Induction of Specific Immunological Tolerance by Combined Kidney and Hematopoietic Stem Cell Transplantation in HLA-Identical Siblings.HLA 同基因兄弟姐妹间联合肾和造血干细胞移植诱导特异性免疫耐受的成功。
Front Immunol. 2022 Jan 31;13:796456. doi: 10.3389/fimmu.2022.796456. eCollection 2022.
8
Immune monitoring of transplant patients in transient mixed chimerism tolerance trials.短暂混合嵌合耐受试验中移植患者的免疫监测
Hum Immunol. 2018 May;79(5):334-342. doi: 10.1016/j.humimm.2017.12.011. Epub 2017 Dec 28.
9
Tolerance induction in HLA disparate living donor kidney transplantation by facilitating cell-enriched donor stem cell Infusion: The importance of durable chimerism.通过促进富含细胞的供体干细胞输注在 HLA 不相合活体供肾移植中诱导免疫耐受：持久嵌合体的重要性。
Hum Immunol. 2018 May;79(5):272-276. doi: 10.1016/j.humimm.2018.01.007. Epub 2018 Mar 2.
10
An investigation to assess the potential of CD25highCD4+ T cells to regulate responses to donor alloantigens in clinically stable renal transplant recipients.一项评估CD25高表达CD4 + T细胞在临床稳定的肾移植受者中调节对供体同种异体抗原反应潜力的研究。
Transpl Int. 2008 Jan;21(1):65-73. doi: 10.1111/j.1432-2277.2007.00560.x. Epub 2007 Sep 20.
引用本文的文献
1
A novel technique for heart-thymus en bloc transplantation in nonhuman primates.一种用于非人灵长类动物心脏-胸腺整块移植的新技术。
Sci Rep. 2024 Dec 30;14(1):31930. doi: 10.1038/s41598-024-83378-4.
2
Foxp3+ regulatory T cell therapy for tolerance in autoimmunity and solid organ transplantation.Foxp3+ 调节性 T 细胞治疗自身免疫和实体器官移植中的免疫耐受。
Front Immunol. 2022 Nov 17;13:1055466. doi: 10.3389/fimmu.2022.1055466. eCollection 2022.
3
Pre-transplant infusion of donor leukocytes treated with extracorporeal photochemotherapy induces immune hypo-responsiveness and long-term allograft survival in murine models.在小鼠模型中，移植前输注经体外光化学疗法处理的供体白细胞可诱导免疫低反应性并实现长期同种异体移植存活。
Sci Rep. 2022 May 4;12(1):7298. doi: 10.1038/s41598-022-11290-w.
4
Establishment of Chimerism and Organ Transplant Tolerance in Laboratory Animals: Safety and Efficacy of Adaptation to Humans.嵌合体的建立与实验动物器官移植耐受：适应人体的安全性和有效性。
Front Immunol. 2022 Feb 10;13:805177. doi: 10.3389/fimmu.2022.805177. eCollection 2022.
5
Cellular Therapies in Solid Organ Allotransplantation: Promise and Pitfalls.实体器官同种异体移植中的细胞治疗：前景与挑战。
Front Immunol. 2021 Aug 30;12:714723. doi: 10.3389/fimmu.2021.714723. eCollection 2021.
6
A Large-Scale Bank of Organ Donor Bone Marrow and Matched Mesenchymal Stem Cells for Promoting Immunomodulation and Transplant Tolerance.大规模供者来源的骨髓和间充质干细胞库促进免疫调节和移植耐受。
Front Immunol. 2021 Feb 26;12:622604. doi: 10.3389/fimmu.2021.622604. eCollection 2021.
7
Tolerance induction with donor hematopoietic stem cell infusion in kidney transplantation: a single-center experience in China with a 10-year follow-up.肾移植中通过输注供体造血干细胞诱导免疫耐受：中国单中心10年随访经验
Ann Transl Med. 2020 Nov;8(21):1378. doi: 10.21037/atm-20-2502a.
本文引用的文献
1
Differential risks for adverse outcomes 3 years after kidney transplantation based on initial immunosuppression regimen: a national study.基于初始免疫抑制方案的肾移植术后3年不良结局的差异风险：一项全国性研究。
Transpl Int. 2016 Nov;29(11):1226-1236. doi: 10.1111/tri.12850. Epub 2016 Sep 28.
2
Nonchimeric HLA-Identical Renal Transplant Tolerance: Regulatory Immunophenotypic/Genomic Biomarkers.非嵌合型 HLA 相同的肾移植耐受性：调节性免疫表型/基因组生物标志物
Am J Transplant. 2016 Jan;16(1):221-34. doi: 10.1111/ajt.13416. Epub 2015 Jul 30.
3
Inhibitory effects of belatacept on allospecific regulatory T-cell generation in humans.贝他赛普对人类同种特异性调节性 T 细胞生成的抑制作用。
Transplantation. 2013 Oct 27;96(8):689-96. doi: 10.1097/TP.0b013e31829f1607.
4
Genomic biomarkers correlate with HLA-identical renal transplant tolerance.基因组生物标志物与 HLA 相同的肾移植耐受相关。
J Am Soc Nephrol. 2013 Sep;24(9):1376-85. doi: 10.1681/ASN.2013010068. Epub 2013 Jun 20.
5
Favorable effects of alemtuzumab on allospecific regulatory T-cell generation.阿仑单抗对同种异体特异性调节性 T 细胞生成的有利影响。
Hum Immunol. 2012 Feb;73(2):141-9. doi: 10.1016/j.humimm.2011.11.008. Epub 2011 Nov 23.
6
Induced immune tolerance for kidney transplantation.肾移植的诱导免疫耐受
N Engl J Med. 2011 Oct 6;365(14):1359-60. doi: 10.1056/NEJMc1107841.
7
Identification of a B cell signature associated with renal transplant tolerance in humans.鉴定与人类肾移植耐受相关的 B 细胞特征。
J Clin Invest. 2010 Jun;120(6):1836-47. doi: 10.1172/JCI39933. Epub 2010 May 24.
8
The human "Treg MLR": immune monitoring for FOXP3+ T regulatory cell generation.人类“Treg混合淋巴细胞反应”：对FOXP3 +调节性T细胞生成的免疫监测
Transplantation. 2009 Dec 15;88(11):1303-11. doi: 10.1097/TP.0b013e3181bbee98.
9
Tolerance and chimerism after renal and hematopoietic-cell transplantation.肾移植和造血细胞移植后的耐受性与嵌合现象。
N Engl J Med. 2008 Jan 24;358(4):362-8. doi: 10.1056/NEJMoa074191.
10
HLA-mismatched renal transplantation without maintenance immunosuppression.无维持免疫抑制的HLA错配肾移植
N Engl J Med. 2008 Jan 24;358(4):353-61. doi: 10.1056/NEJMoa071074.
Zotero 插件