年轻及绝经前子宫内膜样子宫内膜癌患者卵巢受累的危险因素。

Risk factors for ovarian involvement in young and premenopausal endometrioid endometrial cancer patients.

作者信息

Li Jun, Zhu Qin, Yang Bingyi, Ning Chengcheng, Liu Xiaoxia, Luo Xuezhen, Chen Xiaojun

机构信息

Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai 200011, China.

Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China.

出版信息

Eur J Obstet Gynecol Reprod Biol. 2018 Mar;222:151-154. doi: 10.1016/j.ejogrb.2018.01.030. Epub 2018 Jan 31.

DOI:10.1016/j.ejogrb.2018.01.030

PMID:29408747

Abstract

OBJECTIVE

This study aimed to investigate the incidence of ovarian malignant involvement in young and premenopausal endometrioid endometrial cancer and study the possible risk factors.

METHODS

Premenopausal patients 45 years of age or younger with endometrioid endometrial cancer treated at the OB/GYN Hospital of Fudan University between 2009 and 2013 were identified. The incidence of ovarian malignant involvement in young and premenopausal endometrioid endometrial cancer patients were calculated and the possible risk factors were investigated.

RESULTS

A total of 144 younger (age ≤ 45, premenopausal) patients with endometrioid endometrial cancer were identified and coexisting malignant ovarian neoplasms were detected in 6 patients. Univariate analysis revealed that deeper myometrial invasion, positive lymphonode metastasis, positive LVSI, and high histologic grade (G2-G3) were associated with ovarian involvement in younger endometrial cancer patients. However, multivariate analysis revealed that only deep myometrial invasion was an independent risk factors for ovarian involvement (OR = 12.81, P = 0.046).

CONCLUSION

In conclusions, the incidence of coexisting ovarian malignant neoplasms in young and premenopausal patients with endometrioid endometrial cancer is low, and these findings may facilitate preoperative counseling of patients and decision making at the time of surgery.

摘要

目的

本研究旨在调查年轻及绝经前子宫内膜样腺癌患者卵巢恶性受累的发生率，并研究可能的危险因素。

方法

确定2009年至2013年期间在复旦大学附属妇产科医院接受治疗的45岁及以下绝经前子宫内膜样腺癌患者。计算年轻及绝经前子宫内膜样腺癌患者卵巢恶性受累的发生率，并调查可能的危险因素。

结果

共确定了144例年龄较小（年龄≤45岁，绝经前）的子宫内膜样腺癌患者，其中6例检测到并存恶性卵巢肿瘤。单因素分析显示，肌层浸润深度更深、淋巴结转移阳性、LVSI阳性和高组织学分级（G2-G3）与年轻子宫内膜癌患者的卵巢受累有关。然而，多因素分析显示，只有肌层浸润深度是卵巢受累的独立危险因素（OR = 12.81，P = 0.046）。