Khadraoui Wafa, Tierney Christina, Chung Sophie, Mutlu Levent, Lu Lingeng, Azodi Masoud, Ratner Elena, Menderes Gulden
Department of Obstetrics and Gynecology, Yale New Haven Health - Bridgeport Hospital, Bridgeport, CT, USA.
Department of Obstetrics, Gynecology & Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA.
Int J Gynaecol Obstet. 2020 Sep;150(3):385-391. doi: 10.1002/ijgo.13254. Epub 2020 Jun 26.
To establish the rate of occult ovarian micro-metastases in early stage disease and to provide an eligibility framework for providers to consider ovarian preservation in a patient population with presumed early stage disease.
A retrospective review from January 2005 to December 2010 identified women with presumed early stage endometrial cancer from a single institutional database. Inclusion criteria included: (1) FIGO grade 1 endometrioid endometrial cancer on endometrial biopsy; or (2) the same pathology as (1) on frozen section specimen with less than 50% myometrial biopsy; and (3) no evidence of metastatic disease on preoperative imaging or visible metastatic disease in the peritoneal cavity.
Of the 52 patients, 86.5% were diagnosed with stage IA and 11.5% were diagnosed with stage II disease. One patient (1.9%) had microscopic adnexal involvement in a fallopian tube, which upstaged her to stage IIA disease. None of the patients had ovarian involvement.
Preservation of the ovaries appears to be a safe and viable option for premenopausal women who are diagnosed with presumed early stage endometrioid endometrial cancer. It is believed that ovarian preservation in this select population will provide them with significant health benefits and improve their quality of life.
确定早期疾病中隐匿性卵巢微转移的发生率，并为医疗服务提供者在假定为早期疾病的患者群体中考虑保留卵巢提供一个资格框架。
对2005年1月至2010年12月期间的数据进行回顾性分析，从一个单一机构数据库中识别出假定为早期子宫内膜癌的女性患者。纳入标准包括：（1）子宫内膜活检显示为FIGO 1级子宫内膜样癌；或（2）冰冻切片标本的病理与（1）相同，且肌层活检少于50%；以及（3）术前影像学检查无转移疾病证据或腹腔内无可见转移疾病。
52例患者中，86.5%被诊断为IA期，11.5%被诊断为II期疾病。1例患者（1.9%）输卵管有微小附件受累，使其分期升至IIA期。无患者有卵巢受累。
对于被诊断为假定为早期子宫内膜样癌的绝经前女性，保留卵巢似乎是一种安全可行的选择。据信，在这一特定人群中保留卵巢将为她们带来显著的健康益处并改善其生活质量。
