中国老年人群中促卵泡生成素的昼夜节律与非酒精性脂肪性肝病相关。

Diurnal rhythm of follicle-stimulating hormone is associated with nonalcoholic fatty liver disease in a Chinese elderly population.

作者信息

Li Xiaoming, Jing Long, Lin Fang, Huang Huan, Chen Zhizhong, Chen Yan, Wang Lina, Lin Xing, Guo Tailin, Yang Jin, Ruan Jingming, Lin Kaiyang, Li Chunjing, You Zhebing, He Linlin, Chen Jiankang, Li Zhuzhou, Zhu Pengli, Chen Gang

机构信息

Department of Geriatric Medicine, Fujian Provincial Hospital, Fujian Provincial Institute of Clinical Geriatrics, Fujian Provincial Key Laboratory of Geriatric Diseases, Fujian Medical University, Fuzhou, 350001, China.

Department of Pathology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, 350001, China.

出版信息

Eur J Obstet Gynecol Reprod Biol. 2018 Mar;222:166-170. doi: 10.1016/j.ejogrb.2018.01.034. Epub 2018 Jan 31.

DOI:10.1016/j.ejogrb.2018.01.034

PMID:29408750

Abstract

OBJECTIVE

Previous studies have found that impairment of the circadian clock appears to contribute to the development of nonalcoholic fatty liver disease (NAFLD) and the circulating follicle-stimulating hormone (FSH) level showed a diurnal cycle. A recent study reported that a lower FSH level was associated with NAFLD. However, the effects of the diurnal rhythm of FSH on NAFLD have not been reported. The aim of this study was to evaluate whether the diurnal rhythm of FSH was associated with NAFLD in an elderly population.

STUDY DESIGN

We performed a cross-sectional study among 71 elderly patients between August 2015 and November 2015 at Fujian Provincial Hospital. Anthropometrics and tests for laboratory were performed for each patient. FSH was determined by radioimmunoassay. The FSH receptor (FSHR) expression was identified in liver and ovary tissue by immunohistochemical staining. NAFLD was diagnosed by sonographic features.

RESULTS

Of the 71 patients, 33 (42.9%) had NAFLD on their ultrasound. There were no significant differences between subjects with NAFLD and those without NAFLD in terms of age, sex, body mass index, waist-to-hip ratio, fasting plasma glucose, postload plasma glucose, liver enzyme, triglycerides, total cholesterol, high-density lipoprotein-cholesterol and low-density lipoprotein-cholesterol. Both the serum FSH levels of 8AM and 0AM showed no differences between the groups. The proportion of the 'normal' diurnal rhythm of FSH was higher among the patients with NAFLD (78.1% vs. 52.6%, P = .027). After adjusting for all potential confounders, the fully adjusted odds ratios (OR) of diurnal rhythm of FSH for NAFLD was 3.86 (95%CI: 1.01, 14.81, P = .049). Immunohistochemical staining showed that the FSHR protein was detected in human ovarian and hepatic tissues.

CONCLUSIONS

These results suggest that the 'normal' diurnal rhythm of FSH was independently associated with NAFLD in an elderly population. This study provides a novel insight into the diurnal rhythm of FSH in the pathogenesis of NAFLD.

摘要

目的

既往研究发现，昼夜节律时钟功能障碍似乎与非酒精性脂肪性肝病（NAFLD）的发生发展有关，且循环中的促卵泡生成素（FSH）水平呈现昼夜节律变化。最近一项研究报告称，较低的FSH水平与NAFLD相关。然而，FSH昼夜节律对NAFLD的影响尚未见报道。本研究的目的是评估FSH昼夜节律是否与老年人群的NAFLD相关。

研究设计

2015年8月至2015年11月期间，我们在福建省立医院对71例老年患者进行了一项横断面研究。对每位患者进行人体测量和实验室检查。采用放射免疫分析法测定FSH。通过免疫组织化学染色在肝脏和卵巢组织中鉴定FSH受体（FSHR）表达。根据超声特征诊断NAFLD。

结果

71例患者中，33例（42.9%）超声检查发现患有NAFLD。NAFLD患者与非NAFLD患者在年龄、性别、体重指数、腰臀比、空腹血糖、餐后血糖、肝酶、甘油三酯、总胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇方面无显著差异。两组患者上午8点和凌晨0点的血清FSH水平均无差异。NAFLD患者中FSH“正常”昼夜节律的比例较高（78.1%对52.6%，P = 0.027）。在对所有潜在混杂因素进行校正后，FSH昼夜节律对NAFLD的完全校正比值比（OR）为3.86（95%CI：1.01，14.81，P = 0.049）。免疫组织化学染色显示，在人卵巢和肝脏组织中检测到FSHR蛋白。