Duan Huiyan, Gong Minmin, Yuan Gang, Wang Zhi
Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
J Clin Exp Hepatol. 2025 Mar-Apr;15(2):102459. doi: 10.1016/j.jceh.2024.102459. Epub 2024 Nov 19.
The global prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) is rising due to rapid lifestyle changes. Although females may be less prone to MASLD than males, specific studies on MASLD in females should still be conducted. Previous research has shown that sex hormone levels are strongly linked to MASLD in females. By reviewing a large number of experimental and clinical studies, we summarized the pathophysiological mechanisms of estrogen, androgen, sex hormone-binding globulin, follicle-stimulating hormone, and prolactin involved in the development of MASLD. We also analyzed the role of these hormones in female MASLD patients with polycystic ovarian syndrome or menopause, and explored the potential of targeting sex hormones for the treatment of MASLD. We hope this will provide a reference for further exploration of mechanisms and treatments for female MASLD from the perspective of sex hormones.
由于生活方式的迅速改变，代谢功能障碍相关脂肪性肝病（MASLD）的全球患病率正在上升。尽管女性可能比男性更不易患MASLD，但仍应开展关于女性MASLD的具体研究。先前的研究表明，性激素水平与女性MASLD密切相关。通过回顾大量实验和临床研究，我们总结了雌激素、雄激素、性激素结合球蛋白、促卵泡激素和催乳素参与MASLD发生发展的病理生理机制。我们还分析了这些激素在患有多囊卵巢综合征或更年期的女性MASLD患者中的作用，并探讨了以性激素为靶点治疗MASLD的潜力。我们希望这将为从性激素角度进一步探索女性MASLD的发病机制和治疗方法提供参考。
