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选择性堕胎:法国妇产科医师学会(CNGOF)临床实践指南

Elective abortion: Clinical practice guidelines from the French College of Gynecologists and Obstetricians (CNGOF).

作者信息

Vayssière Christophe, Gaudineau Adrien, Attali Luisa, Bettahar Karima, Eyraud Sophie, Faucher Philippe, Fournet Patrick, Hassoun Danielle, Hatchuel Marie, Jamin Christian, Letombe Brigitte, Linet Teddy, Msika Razon Marie, Ohanessian Alexandra, Segain Hélène, Vigoureux Solène, Winer Norbert, Wylomanski Sophie, Agostini Aubert

机构信息

Pôle Femme-Mère-Couple, service de gynecologie-obstétrique, Hôpital Paule de Viguier, CHU de Toulouse, Toulouse, France; UMR 1027 INSERM, Université Paul-Sabatier Toulouse III, Toulouse, France.

Département de Gynécologie-Obstétrique, Hôpital de Hautepierre, CHU de Strasbourg, 1 avenue Molière, 67098 Strasbourg, France.

出版信息

Eur J Obstet Gynecol Reprod Biol. 2018 Mar;222:95-101. doi: 10.1016/j.ejogrb.2018.01.017. Epub 2018 Jan 31.

DOI:10.1016/j.ejogrb.2018.01.017
PMID:
29408754
Abstract

The number of elective abortions has been stable for several decades. Many factors explain women's choice of abortion in cases of unplanned pregnancies. Early initiation of contraceptive use and a choice of contraceptive choices appropriate to the woman's life are associated with lower rates of unplanned pregnancies. Reversible long-acting contraceptives should be favored as first-line methods for adolescents because of their effectiveness (grade C). Ultrasound scan before an elective abortion must be encouraged but should not be obligatory (professional consensus). As soon as the embryo appears on the ultrasound scan, the date of pregnancy is estimated by measuring the crown-rump length (CRL) or, from 11 weeks on, by measuring the biparietal diameter (BPD) (grade A). Because reliability of these parameters is ±5 days, the abortion may be done if measurements are respectively less than 90 mm for CRL and less than 30 mm for BPD (professional consensus). A medically induced abortion, performed with a dose of 200 mg mifepristone combined with misoprostol, is effective at any gestational age (Level of Evidence (LE) 1). Before 7 weeks, mifepristone should be followed 24-48 h later by misoprostol, administered orally, buccally, sublingually, or even vaginally followed if needed by a further dose of 400 μg after 3 h, to be renewed if needed after 3 h (LE 1, grade A). After 7 weeks, administration of misoprostol by the vaginal, sublingual, or buccal routes is more effective and better tolerated than by the oral route (LE 1). Cervical preparation is recommended for systematic use in surgical abortions (professional consensus). Misoprostol is a first-line agent for cervical preparation at a dose of 400 μg (grade A). Vacuum aspiration is preferable to curettage (grade B). A uterus perforated during surgical aspiration should not routinely be considered to be scarred (professional consensus). An elective abortion is not associated with a higher risk of subsequent infertility or ectopic pregnancy (LE 2). The medical consultation before an elective abortion generally does not affect the decision to end or continue the pregnancy, and most women are sufficiently certain about their choice at this time. Women appear to find the method used most acceptable and to be most satisfied when they were able to choose the method (grade B). Elective abortions are not associated with an increased rate of psychiatric disorders (LE 2). However, women with psychiatric histories are at a higher risk of psychological disorders after the occurrence of an unplanned pregnancy than women with such a history (LE 2). For surgical abortions, combined hormonal contraceptives - oral or transdermal - should be started on the day of the abortion, while the vaginal ring should be inserted 5 days afterwards (grade B). For medical abortions, the vaginal ring should be inserted in the week after mifepristone administration, while the combined contraceptives should begin the same day as the misoprostol or the day after (grade C). Contraceptive implants should be inserted on the same day as a surgical abortion, and may be inserted the day the mifepristone is administered for medical abortions (grade B and C respectively). In case of medical abortion, the implant can be inserted the same day the mifepristone is administered (grade C). Both the copper IUDs and levonorgestrel intrauterine system should be inserted on the day of the surgical abortion (grade A). After medical abortions, an IUD can be inserted in 10 days after mifepristone administration, after ultrasound scan verification of the absence of an intrauterine pregnancy (grade C).

摘要

几十年来,选择性堕胎的数量一直保持稳定。许多因素可以解释女性在意外怀孕情况下选择堕胎的原因。尽早开始使用避孕药具以及选择适合女性生活的避孕方式与较低的意外怀孕率相关。由于其有效性(C级),可逆长效避孕药应作为青少年的一线避孕方法。必须鼓励在选择性堕胎前进行超声检查,但不应强制要求(专业共识)。一旦胚胎在超声检查中出现,可通过测量头臀长度(CRL)来估计怀孕日期,从孕11周起,也可通过测量双顶径(BPD)来估计(A级)。由于这些参数的可靠性为±5天,如果CRL分别小于90毫米且BPD小于30毫米,则可进行堕胎(专业共识)。采用200毫克米非司酮联合米索前列醇进行药物流产,在任何孕周均有效(证据级别(LE)1)。孕7周前,米非司酮服用24 - 48小时后应服用米索前列醇,可口服、颊含、舌下含服,甚至经阴道给药,如有需要,3小时后可再服用400微克剂量,3小时后如有需要可重复给药(LE 1,A级)。孕7周后,经阴道、舌下或颊含途径给药的米索前列醇比口服途径更有效且耐受性更好(LE 1)。建议在手术流产时常规使用宫颈准备(专业共识)。米索前列醇是宫颈准备的一线药物,剂量为400微克(A级)。负压吸引术优于刮宫术(B级)。手术吸引过程中子宫穿孔的情况通常不认为会导致子宫瘢痕形成(专业共识)。选择性堕胎与随后不孕的风险升高无关(LE 2)。选择性堕胎前的医学咨询通常不会影响终止或继续妊娠的决定,大多数女性此时对自己的选择相当确定。当女性能够选择堕胎方法时,她们似乎认为所使用的方法最可接受且最满意(B级)。选择性堕胎与精神障碍发生率的增加无关(LE 2)。然而,有精神病史的女性在意外怀孕后出现心理障碍的风险高于无此病史的女性(LE 2)。对于手术流产,口服或经皮的复方激素避孕药应在流产当天开始服用,而阴道环应在流产后5天插入(B级)。对于药物流产,阴道环应在服用米非司酮后的一周内插入,而复方避孕药应在服用米索前列醇的当天或次日开始服用(C级)。避孕植入剂应在手术流产当天插入,药物流产时可在服用米非司酮的当天插入(分别为B级和C级)。药物流产时,植入剂可在服用米非司酮的当天插入(C级)。铜宫内节育器和左炔诺孕酮宫内节育系统均应在手术流产当天插入(A级)。药物流产后,在超声检查确认宫内无妊娠后,可在服用米非司酮10天后插入宫内节育器(C级)。

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