Workplace Mental Health Institute, Kangbuk Samsung Hospital, Seoul, Republic of Korea.
Department of Psychiatry, Soonchunhyang University Cheonan Hospital, Cheonan, Republic of Korea.
J Clin Endocrinol Metab. 2018 May 1;103(5):1827-1833. doi: 10.1210/jc.2017-01247.
The role of subclinical hypothyroidism in the development of depression remains controversial. We examined the prospective association between subclinical hypothyroidism and incident depressive symptoms.
We conducted a prospective cohort study of 220,545 middle-age adults without depression who had undergone at least two comprehensive health examinations between 1 January 2011 and 31 December 2014. Thyroid-stimulating hormone, free triiodothyronine (FT3), and free thyroxine (FT4) levels were measured using an electrochemiluminescent immunoassay. The study outcome was incident depressive symptoms, defined as a Center for Epidemiologic Studies-Depression score >16.
During a median follow-up period of 2 years, incident depressive symptoms occurred in 7323 participants. The multivariable-adjusted hazard ratio for incident depressive symptoms comparing subclinical hypothyroid and euthyroid participants was 0.97 (95% confidence interval, 0.87 to 1.09). Similarly, among euthyroid participants (n = 87,822), no apparent association was found between thyroid hormone levels and an increased risk of incident depressive symptoms.
No apparent association was found between subclinical hypothyroidism and incident depressive symptoms in a large prospective cohort of middle-age men and women.
亚临床甲状腺功能减退症在抑郁症发展中的作用仍存在争议。我们研究了亚临床甲状腺功能减退症与新发抑郁症状之间的前瞻性关联。
我们对 220545 名无抑郁的中年成年人进行了前瞻性队列研究，这些人在 2011 年 1 月 1 日至 2014 年 12 月 31 日期间至少接受了两次全面健康检查。使用电化学发光免疫测定法测量促甲状腺激素、游离三碘甲状腺原氨酸（FT3）和游离甲状腺素（FT4）水平。研究结果是新发抑郁症状，定义为流行病学研究中心抑郁评分>16。
在中位随访 2 年期间，7323 名参与者发生了新发抑郁症状。与亚临床甲状腺功能减退和甲状腺功能正常的参与者相比，新发抑郁症状的多变量调整风险比为 0.97（95%置信区间，0.87 至 1.09）。同样，在甲状腺功能正常的参与者（n=87822）中，甲状腺激素水平与新发抑郁症状风险增加之间似乎没有关联。
在一项针对中年男女的大型前瞻性队列研究中，亚临床甲状腺功能减退症与新发抑郁症状之间似乎没有关联。
