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左甲状腺素钠（LT3）治疗对一名患有甲状腺功能减退症且脱碘酶基因多态性患者抑郁症的改善作用。

Improvement of depression in a patient with hypothyroidism and deiodinase polymorphism with LT3 Therapy.

作者信息

Ahmed Ziyan S, Sherin Rinsha P V, Fonseca Tatiana L, Hoang Thanh D, Shakir Mohamed K M

机构信息

Endocrinology Division Walter Reed National Military Medical Center Bethesda Maryland USA.

Section of Adult and Pediatric Endocrinology Diabetes & Metabolism University of Chicago Chicago Illinois USA.

出版信息

Clin Case Rep. 2022 Apr 12;10(4):e05651. doi: 10.1002/ccr3.5651. eCollection 2022 Apr.

DOI:10.1002/ccr3.5651
PMID:35432999
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9005678/
Abstract

We report a 54-year-old man with treatment-resistant depression (TRD) and hypothyroidism who responded to LT3/LT4 combination, rather than LT4 alone. He was able to discontinue all antidepressant medications eventually. Interestingly, the patient has a DIO2 polymorphism.

摘要

我们报告了一名54岁患有难治性抑郁症（TRD）和甲状腺功能减退症的男性，他对左甲状腺素钠（LT3）/左甲状腺素（LT4）联合治疗有反应，而不是单独使用LT4。他最终能够停用所有抗抑郁药物。有趣的是，该患者存在二碘甲状腺原氨酸脱碘酶2（DIO2）基因多态性。

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本文引用的文献

1
-Adenosylmethionine (SAMe) in major depressive disorder (MDD): a clinician-oriented systematic review.- 腺苷蛋氨酸（SAMe）在重度抑郁症（MDD）中的应用：一项面向临床医生的系统评价
Ann Gen Psychiatry. 2020 Sep 5;19:50. doi: 10.1186/s12991-020-00298-z. eCollection 2020.
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Pharmacological Treatments for Patients with Treatment-Resistant Depression.难治性抑郁症患者的药物治疗
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Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain.
2 型脱碘酶多态性导致大脑内质网应激和甲状腺功能减退。
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A Common DIO2 Polymorphism and Alzheimer Disease Dementia in African and European Americans.DIO2 常见多态性与非裔美国人和欧洲裔美国人的阿尔茨海默病痴呆。
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Diagnosed thyroid disorders are associated with depression and anxiety.被诊断出的甲状腺疾病与抑郁和焦虑有关。
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Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task force on thyroid hormone replacement.甲状腺功能减退症治疗指南：由美国甲状腺协会甲状腺激素替代特别工作组制定。
Thyroid. 2014 Dec;24(12):1670-751. doi: 10.1089/thy.2014.0028.
8
Desiccated thyroid extract compared with levothyroxine in the treatment of hypothyroidism: a randomized, double-blind, crossover study.干甲状腺提取物与左甲状腺素治疗甲状腺功能减退症的比较：一项随机、双盲、交叉研究。
J Clin Endocrinol Metab. 2013 May;98(5):1982-90. doi: 10.1210/jc.2012-4107. Epub 2013 Mar 28.
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Depression in patients with euthyroid chronic autoimmune thyroiditis.甲状腺功能正常的慢性自身免疫性甲状腺炎患者的抑郁。
Endocr J. 2012;59(8):705-8. doi: 10.1507/endocrj.ej12-0035. Epub 2012 May 12.
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PLoS One. 2011;6(8):e22552. doi: 10.1371/journal.pone.0022552. Epub 2011 Aug 1.