Aujla Randeep S, Allen Patricia E, Ribbans William J
Trauma & Orthopaedic Surgery, University Hospitals of Leicester, Leicester, United Kingdom.
The University of Northampton, Northampton, The County Clinic Northampton, England, United Kingdom.
Foot Ankle Surg. 2019 Jun;25(3):310-315. doi: 10.1016/j.fas.2017.12.007. Epub 2017 Dec 23.
Vitamin D deficiency is a global concern impacting upon large communities and certain disease populations. It can adversely affect the outcome of orthopaedic operations. We aimed to perform an audit of the Vitamin D status of patients in two centres in the United Kingdom undergoing elective foot and ankle surgery.
Serum 25-hydroxyvitamin-D (vitamin D) levels were obtained prospectively in 577 consecutive elective patients undergoing elective foot and ankle surgery between October 2014 and March 2017 (29 months). Variables including age, gender, ethnicity, location, season, month and procedure type were recorded.
577 patients were included over the study period. 62.0% were female. Mean age was 53.2 (median 54.5, range 16.7-86.6). 300 patients were treated in Northampton and 277 in Leicester. The serum 25-hydroxyvitamin-D levels for the patient group were normally distributed. The mean was 52.3nmol/L (SD 28.0; range 7.5-175) and the median 47.5nmol/L. 21.7% were grossly deficient, 31.9% deficient, 28.9% insufficient and 17.5% within normal range. Age, gender and procedure type did not statistically affect vitamin D levels (p=0.5, t-test). Ethnicity, location and Winter season did affect Vitamin D levels (p<0.05). August was the most significant month with levels significantly higher than January, February, March, April, June, November and December (p<0.05, one-way ANOVA).
Only 1 in 5.7 patients had a normal Vitamin D level and 1 in 4.6 were grossly deficient. Ethnicity and patient location significantly affected Vitamin D results. Summer months were noted to demonstrate significantly the highest levels and August the highest. We did not find that age or gender affected Vitamin D levels in our cohort.
维生素D缺乏是一个全球性问题,影响着众多群体和某些疾病人群。它会对骨科手术的结果产生不利影响。我们旨在对英国两个中心接受择期足踝手术的患者的维生素D状况进行一次审计。
在2014年10月至2017年3月(29个月)期间,前瞻性地获取了577例连续接受择期足踝手术的患者的血清25-羟维生素D(维生素D)水平。记录了包括年龄、性别、种族、地点、季节、月份和手术类型等变量。
在研究期间纳入了577例患者。62.0%为女性。平均年龄为53.2岁(中位数54.5岁,范围16.7 - 86.6岁)。300例患者在北安普敦接受治疗,277例在莱斯特接受治疗。患者组的血清25-羟维生素D水平呈正态分布。平均值为52.3nmol/L(标准差28.0;范围7.5 - 175),中位数为47.5nmol/L。21.7%严重缺乏,31.9%缺乏,28.9%不足,17.5%在正常范围内。年龄、性别和手术类型对维生素D水平无统计学影响(p = 0.5,t检验)。种族、地点和冬季确实会影响维生素D水平(p < 0.05)。8月是最显著的月份,其水平显著高于1月、2月、3月、4月、6月、11月和12月(p < 0.05,单因素方差分析)。
每5.7例患者中只有1例维生素D水平正常,每4.6例中有1例严重缺乏。种族和患者地点显著影响维生素D结果。夏季月份的维生素D水平显著最高,8月最高。我们未发现年龄或性别对我们队列中的维生素D水平有影响。