1 Department of Experimental Hematology, Beijing Institute of Radiation Medicine , Beijing, P.R. China .
2 Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine , Beijing, P.R. China .
Hum Gene Ther. 2018 Apr;29(4):413-423. doi: 10.1089/hum.2017.217. Epub 2018 Mar 28.
Stem cells and gene therapy have become promising strategies for treating ischemic diseases and regenerating tissue. Hepatocyte growth factor (HGF) is an angiogenic growth factor with multiple functions, including promoting angiogenesis, regulating inflammation, inhibiting fibrosis, and activating tissue regeneration. Numerous preclinical experiments and clinical trials have demonstrated the feasibility and efficacy of HGF gene therapy in the treatment of ischemic diseases and tissue regeneration. This review summarizes the current advances of therapeutic angiogenesis using HGF gene transfer and modified stem cells. The physiological roles of HGF in angiogenesis and tissue regeneration are revisited. The current advances of clinical trials of plasmid and adenovirus HGF in the treatment of critical limb ischemia and coronary heart disease in China are introduced. Furthermore, valuable insight is provided into the prospective future of novel regenerative strategies using HGF-modified mesenchymal stem cells. HGF gene therapy is presented as a promising therapeutic approach in the treatment of ischemic diseases and regenerative medicine.
干细胞和基因治疗已成为治疗缺血性疾病和组织再生的有前途的策略。肝细胞生长因子（HGF）是一种具有多种功能的血管生成生长因子，包括促进血管生成、调节炎症、抑制纤维化和激活组织再生。大量的临床前实验和临床试验已经证明了 HGF 基因治疗在治疗缺血性疾病和组织再生方面的可行性和疗效。本综述总结了使用 HGF 基因转移和修饰干细胞进行治疗性血管生成的最新进展。重新审视了 HGF 在血管生成和组织再生中的生理作用。介绍了中国在治疗严重肢体缺血和冠心病中使用质粒和腺病毒 HGF 的临床试验的最新进展。此外，还对使用 HGF 修饰间充质干细胞的新型再生策略的未来前景提供了有价值的见解。HGF 基因治疗是治疗缺血性疾病和再生医学的一种很有前途的治疗方法。
