Ebenebe Obialunanma V, Heather Alison, Erickson Jeffrey R
Department of Physiology, School of Medical Sciences and HeartOtago, University of Otago, Dunedin, Otago, New Zealand.
Department of Physiology, School of Medical Sciences and HeartOtago, University of Otago, Dunedin, Otago, New Zealand.
Heart Lung Circ. 2018 May;27(5):560-567. doi: 10.1016/j.hlc.2017.12.003. Epub 2017 Dec 19.
Signalling mechanisms within and between cells of the vasculature enable function and maintain homeostasis. However, a number of these mechanisms also contribute to the pathophysiology of vascular disease states. The multifunctional signalling molecule calcium/calmodulin-dependent kinase II (CaMKII) has been shown to have critical functional effects in many tissue types. For example, CaMKII is known to have a dual role in cardiac physiology and pathology. The function of CaMKII within the vasculature is incompletely understood, but emerging evidence points to potential physiological and pathological roles. This review discusses the evidence for CaMKII signalling within the vasculature, with the aim to better understand both positive and potentially deleterious effects of CaMKII activation in vascular tissue.
脉管系统细胞内和细胞间的信号传导机制维持其功能并保持体内平衡。然而，这些机制中的许多也促成了血管疾病状态的病理生理学。多功能信号分子钙/钙调蛋白依赖性激酶II（CaMKII）已被证明在许多组织类型中具有关键的功能作用。例如，CaMKII在心脏生理学和病理学中具有双重作用。CaMKII在脉管系统中的功能尚未完全了解，但新出现的证据表明其具有潜在的生理和病理作用。本综述讨论了脉管系统中CaMKII信号传导的证据，旨在更好地理解CaMKII激活在血管组织中的积极和潜在有害作用。
