Erickson Jeffrey R, Anderson Mark E
Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242-1109, USA.
J Cardiovasc Electrophysiol. 2008 Dec;19(12):1332-6. doi: 10.1111/j.1540-8167.2008.01295.x. Epub 2008 Sep 17.
Calcium/calmodulin-dependent kinase II (CaMKII) is a multifunctional serine/threonine kinase widely distributed in a number of tissue types. Activation of CaMKII has been linked to important downstream physiological processes, including apoptosis, hypertrophy, and arrhythmia in the heart. Pharmacological or genetic inhibition of CaMKII has been shown to improve health outcomes in a number of animal models. In this review, we summarize the structural and functional properties of CaMKII and detail its role in cardiac arrhythmia, structural heart disease, and sudden death.
钙/钙调蛋白依赖性激酶II（CaMKII）是一种多功能丝氨酸/苏氨酸激酶，广泛分布于多种组织类型中。CaMKII的激活与重要的下游生理过程有关，包括心脏中的细胞凋亡、肥大和心律失常。在许多动物模型中，CaMKII的药理学或遗传学抑制已显示可改善健康结局。在本综述中，我们总结了CaMKII的结构和功能特性，并详细阐述了其在心律失常、结构性心脏病和猝死中的作用。
