具有抗细胞凋亡活性的麦角灵型生物碱的合成类似物。
Synthetic analogues of the montanine-type alkaloids with activity against apoptosis-resistant cancer cells.
机构信息
Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX 78666, United States.
Laboratoire de Cancérologie et de Toxicologie Expérimentale, Faculté de Pharmacie, Université Libre de Bruxelles (ULB), Brussels, Belgium.
出版信息
Bioorg Med Chem Lett. 2018 Feb 15;28(4):589-593. doi: 10.1016/j.bmcl.2018.01.041. Epub 2018 Feb 2.
Abstract
In a search of small molecules active against apoptosis-resistant cancer cells, a skeletal rearrangement of alkaloid haemanthamine was utilized to generate a series of compounds possessing the alkaloid montanine ring system. The synthesized compounds were found to inhibit proliferation of cancer cells resistant to apoptosis at micromolar concentrations. Selected compounds were also active against patient-derived glioblastoma cells expressing stem-cell markers. This is the first report describing the preparation of synthetic analogues of the montanine-type alkaloids with antiproliferative activity. The compounds prepared in the current investigation appear to be a useful starting point for the development of agents to fight cancers with apoptosis resistance, and thus, associated with poor prognoses.
摘要
在寻找针对抗凋亡癌细胞的小分子的研究中，利用生物碱血根碱的骨架重排生成了一系列具有生物碱芒柄花素环系统的化合物。合成的化合物在微摩尔浓度下即可抑制抗凋亡的癌细胞增殖。选定的化合物对表达干细胞标志物的患者来源的神经胶质瘤细胞也具有活性。这是首次描述具有抗增殖活性的芒柄花素型生物碱的合成类似物的制备方法。本研究中制备的化合物似乎是开发针对抗凋亡的癌症的药物的有用起点，这些癌症与预后不良相关。
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