Allelopathy Group, Department of Organic Chemistry, Institute of Biomolecules (INBIO), School of Science, University of Cadiz, C/Republica Saharaui, s/n, 11510 Puerto Real, Spain.
Department of Chemical Sciences, University of Naples "Federico II", Complesso Universitario Monte Sant'Angelo, Via Cintia 4, 80126 Napoli, Italy.
Biomolecules. 2022 Jul 24;12(8):1025. doi: 10.3390/biom12081025.
Alkaloids are a wide family of basic -containing natural products, whose research has revealed bioactive compounds of pharmacological interest. Studies on these compounds have focused more attention on those produced by plants, although other types of organisms have also been proven to synthesize bioactive alkaloids, such as animals, marine organisms, bacteria, and fungi. This review covers the findings of the last 20 years (2002-2022) related to the isolation, structures, and biological activities of the alkaloids produced by mushrooms, a fungal subgroup, and their potential to develop drugs and agrochemicals. In some cases, the synthesis of the reviewed compounds and structure-activity relationship studies have been described.
生物碱是一类广泛存在的含碱性基团的天然产物，其研究揭示了具有药理学意义的生物活性化合物。这些化合物的研究主要集中在植物来源的生物碱上，尽管其他类型的生物也被证明能够合成具有生物活性的生物碱，如动物、海洋生物、细菌和真菌。本文综述了过去 20 年（2002-2022 年）与蘑菇（真菌亚群）产生的生物碱的分离、结构和生物活性相关的研究结果，以及它们在药物和农用化学品开发方面的潜力。在某些情况下，还描述了所综述化合物的合成和构效关系研究。
