Berk M A, Lorincz A L
Arch Dermatol. 1986 Jun;122(6):670-4.
Patients with moderate to severe bullous pemphigoid are usually treated with systemic corticosteroids. Four patients were treated with tetracycline hydrochloride and niacinamide because of the steroid-sparing anti-inflammatory properties of these agents. An excellent clinical response free of side effects was observed in all patients. The lesions recurred whenever treatment was discontinued. It is believed that these drugs suppress the complement-mediated inflammatory response at the basement membrane zone by suppressing neutrophil chemotaxis and mediators of the inflammatory response in this bullous disease.
中重度大疱性类天疱疮患者通常采用全身性皮质类固醇进行治疗。由于盐酸四环素和烟酰胺具有节省类固醇的抗炎特性，4名患者接受了这两种药物的治疗。所有患者均观察到良好的临床反应且无副作用。每当治疗中断时，皮损就会复发。据信，这些药物通过抑制中性粒细胞趋化性和这种大疱性疾病中炎症反应的介质，来抑制基底膜区补体介导的炎症反应。
