Goon A T, Tan S H, Khoo L S, Tan T
National Skin Centre, Singapore.
Singapore Med J. 2000 Jul;41(7):327-30.
To study the efficacy of tetracycline (or doxycycline) and nicotinamide in the treatment of less extensive bullous pemphigoid.
An open trial of 11 patients with bullous pemphigoid. Treatment was initiated with tetracycline 1.5-2 g/day and nicotinamide 1.5-2 g/day and gradually tapered down. Doxycycline was substituted for tetracycline in patients who could not tolerate tetracycline due to gastrointestinal side effects or headache.
6 out of 11 patients achieved complete response (> 90% decrease in lesions) while another 2 had partial response (50-90% decrease in lesions).
Tetracycline/doxycycline and nicotinamide is a useful alternative treatment for localized bullous pemphigoid, especially in those whose concurrent medical illnesses preclude the use of systemic corticosteroids.
研究四环素（或强力霉素）和烟酰胺治疗面积较小的大疱性类天疱疮的疗效。
对11例大疱性类天疱疮患者进行开放性试验。治疗起始剂量为四环素1.5 - 2克/天和烟酰胺1.5 - 2克/天，并逐渐减量。因胃肠道副作用或头痛而不能耐受四环素的患者，用强力霉素替代四环素。
11例患者中，6例获得完全缓解（皮损减少>90%），另外2例部分缓解（皮损减少50 - 90%）。
四环素/强力霉素和烟酰胺是局限性大疱性类天疱疮的一种有效替代治疗方法，尤其适用于那些并存疾病妨碍使用全身性皮质类固醇激素的患者。
