5-羟色胺调节对内侧前额叶连接强度和稳定性的影响：西酞普兰的药物 fMRI 研究。
The effects of serotonin modulation on medial prefrontal connectivity strength and stability: A pharmacological fMRI study with citalopram.
机构信息
Centre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; South London and Maudsley NHS Foundation Trust, UK.
Centre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, University College London, London, UK; Wellcome Trust Centre for Neuroimaging, University College London, London, UK.
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jun 8;84(Pt A):152-159. doi: 10.1016/j.pnpbp.2018.01.021. Epub 2018 Feb 1.
BACKGROUND
Static and dynamic functional connectivity are being increasingly used to measure the effects of disease and a range of different interventions on brain networks. While preliminary evidence suggests that static connectivity can be modulated by chronic antidepressants administration in healthy individuals and in major depression, much less is known about the acute effects of antidepressants especially on dynamic functional connectivity changes. Here we examine acute effects of antidepressants on dynamic functional connectivity within the default mode network. The default mode network is a well described network with many functions in which the role of serotonin is not clear.
METHODS
In this work we measured acute pharmacological effects of an infusion of the selective serotonin reuptake inhibitor (SSRI) citalopram (10 mg) in a sample of thirteen healthy volunteers randomised to receive on two occasions the active compound or placebo in a cross over dosing.
RESULTS
Acute citalopram administration relative to placebo increased static connectivity between the medial prefrontal cortex and right dorsolateral prefrontal cortex and posterior cingulate cortex. The SSRI also induced a reduction in variability of connectivity with the medial prefrontal cortex in the precuneus and posterior cingulate cortex.
DISCUSSION
The measured changes are compatible with modified serotonin cortical availability.
背景
静息态和动态功能连接正越来越多地被用于测量疾病和一系列不同干预措施对脑网络的影响。虽然初步证据表明，在健康个体和重度抑郁症中，慢性抗抑郁药治疗可以调节静息态连接，但对于抗抑郁药特别是对动态功能连接变化的急性影响知之甚少。在这里，我们研究了抗抑郁药对默认模式网络内动态功能连接的急性影响。默认模式网络是一个具有许多功能的网络，其中血清素的作用尚不清楚。
方法
在这项工作中，我们测量了选择性 5-羟色胺再摄取抑制剂（SSRI）西酞普兰（10mg）在 13 名健康志愿者中的急性药物作用，这些志愿者随机接受两次交叉给药的活性化合物或安慰剂。
结果
与安慰剂相比，西酞普兰的急性给药增加了内侧前额叶皮层和右侧背外侧前额叶皮层以及后扣带回之间的静息态连接。SSRI 还诱导了内侧前额叶皮层与楔前叶和后扣带回之间连接可变性的降低。
讨论
所测量的变化与皮质中血清素可用性的改变一致。
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