Department of Neurosurgery, Ulsan University Hospital, University of Ulsan College of Medicine, 877, Bangeojin sunhwando-ro, Dong-gu, 44033 Ulsan, Republic of Korea.
Department of Neurosurgery, Ulsan University Hospital, University of Ulsan College of Medicine, 877, Bangeojin sunhwando-ro, Dong-gu, 44033 Ulsan, Republic of Korea.
J Neuroradiol. 2018 Sep;45(5):310-315. doi: 10.1016/j.neurad.2017.12.022. Epub 2018 Feb 2.
The purpose of this study was to verify changes in diffusion tensor imaging (DTI) factors in patients with brain metastases treated with stereotactic radiotherapy (SRT). We also investigated the impact of SRT on peritumoral volumes though the use of DTI.
A total of 28 patients with brain metastases who had undergone SRT between March 2014 and December 2015 were enrolled. Magnetic resonance imaging with DTI factors, such as fractional anisotropy (FA) and apparent diffusion tensor (ADC) value, was performed 1 day before the procedure and 3 months after the procedure. DTI data from tumor lesions, edema volumes, and the volumes that received 12Gy were measured.
Tumor volume (P=0.001) and ADC values in the volumes that received 12Gy (P=0.018) and the edema volumes (P=0.003) significantly decreased after the procedure. Decreases in tumor volume were only correlated with decreases in edema volumes (P<0.001). Decreases in edema volumes were correlated with increases in FA values and decreases in ADC values of the volumes that received 12Gy [P=0.019 (FA)/0.002 (ADC)] and the edema volumes [P=0.011 (FA)/0.002 (ADC)].
It was possible to quantify changes in peritumoral volumes in patients with brain metastases after SRT by using DTI. ADC values of peritumoral volumes decreased significantly after SRT. Therefore, it was confirmed through DTI that performing SRT on tumor lesions has a positive effect on the structure and function of peritumoral volumes.
本研究旨在验证接受立体定向放射治疗（SRT）的脑转移瘤患者弥散张量成像（DTI）因子的变化。我们还通过 DTI 研究 SRT 对肿瘤周围体积的影响。
共纳入 2014 年 3 月至 2015 年 12 月期间接受 SRT 的 28 例脑转移瘤患者。在治疗前 1 天和治疗后 3 个月进行 DTI 因素（如分数各向异性（FA）和表观弥散张量（ADC）值）磁共振成像。测量肿瘤病变、水肿体积和接受 12Gy 的体积的 DTI 数据。
治疗后肿瘤体积（P=0.001）和接受 12Gy 的体积（P=0.018）和水肿体积（P=0.003）的 ADC 值显著降低。肿瘤体积的减少仅与水肿体积的减少相关（P<0.001）。水肿体积的减少与接受 12Gy 的体积和水肿体积的 FA 值增加以及 ADC 值降低相关[P=0.019（FA）/0.002（ADC）]和水肿体积[P=0.011（FA）/0.002（ADC）]。
通过 DTI 可以定量评估脑转移瘤患者 SRT 后肿瘤周围体积的变化。SRT 后肿瘤周围体积的 ADC 值显著降低。因此，通过 DTI 证实，对肿瘤病变进行 SRT 对肿瘤周围体积的结构和功能有积极影响。
