University of Mississippi Medical Center Department of Medicine, Jackson; University of Mississippi Medical Center Department of Pediatrics, Jackson; Mississippi Public Broadcasting, Jackson.
University of Mississippi Medical Center Department of Medicine, Jackson.
Am J Med. 2018 Jun;131(6):595-601. doi: 10.1016/j.amjmed.2017.12.045. Epub 2018 Feb 1.
Epidemics of opioid use are old news in the United States, but an epidemic that kills over 200,000 Americans is not. A multiplicity of intertwined factors have brought us to this place. From 30,000 feet, it is the story of good intentions gone bad, a drug industry gone rogue, and government watch dog agencies gone to sleep. At ground level, it is the story of physicians unfamiliar with addictive drugs and drug addiction, new long-acting opioids deceptively marketed, cheap black tar heroin, encouragement to use opioids for chronic noncancer pain by professional organizations with conflicts of interest and without science, a culture intolerant to pain and tolerant to drug use, and the greedy response of the pharmaceutical industry and drug cartels to an expanding market opportunity. These factors are among those that have joined to form a tsunami of addiction and deaths that keeps on coming. A better understanding of them could speed the end of the present cycle of opioid abuse, perhaps prevent others, and inform future decisions about pain management.
在美国,阿片类药物滥用的流行已经不是什么新鲜事了,但造成超过 20 万美国人死亡的流行疫情却鲜为人知。多种错综复杂的因素导致了我们目前的局面。从 30000 英尺的高度俯瞰,这是一个好心办坏事、制药业肆无忌惮、政府监管机构失职的故事。在地面上,这是一个医生不熟悉成瘾性药物和药物成瘾、新型长效阿片类药物被误导性地推向市场、廉价的黑焦油海洛因、有利益冲突且缺乏科学依据的专业组织鼓励将阿片类药物用于慢性非癌症疼痛、对疼痛容忍而对药物使用宽容的文化,以及制药行业和贩毒集团对不断扩大的市场机会的贪婪回应的故事。这些因素共同构成了一波又一波的成瘾和死亡浪潮。更好地理解这些因素可能会加速目前阿片类药物滥用周期的结束,或许可以防止其他类似情况发生,并为未来的疼痛管理决策提供信息。