Centre for Blood Research, University of British Columbia, Vancouver, Canada; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, Canada.
Centre for Blood Research, University of British Columbia, Vancouver, Canada; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, Canada; Faculty of Dentistry, University of British Columbia, Vancouver, Canada.
Chem Biol Interact. 2018 Mar 25;284:1-11. doi: 10.1016/j.cbi.2018.01.015. Epub 2018 Feb 2.
Thrombocytopenia is a serious and potentially fatal complication of drug therapy that results either from a decrease in bone marrow platelet production or the excessive destruction of circulating platelets. Although multiple mechanisms are responsible for deregulated platelet clearance, the role of programmed platelet death (apoptosis) in drug-induced thrombocytopenia has been relatively under-investigated until recently. Here we review apoptotic signaling pathways in platelets, with a focus on current data that provide mechanistic insights into drug-induced apoptosis and thrombocytopenia.
血小板减少症是药物治疗的一种严重且潜在致命的并发症，其原因要么是骨髓血小板生成减少，要么是循环血小板过度破坏。虽然有多种机制导致血小板清除失调，但程序性血小板死亡（细胞凋亡）在药物诱导的血小板减少症中的作用直到最近才得到相对较少的研究。在这里，我们综述了血小板中的凋亡信号通路，并重点介绍了目前提供药物诱导凋亡和血小板减少症机制见解的数据。
