Benderro Girriso F, Gamble Jenniffer, Schiefer Matthew A, Baskin Jonathan Z, Hernandez Yeritza, Strohl Kingman P
Department of Medicine, Division of Puelmonary, Critical Care, and Sleep Medicine, Case Western Reserve University, Cleveland, OH, United States.
Department of Medicine, Division of Puelmonary, Critical Care, and Sleep Medicine, Case Western Reserve University, Cleveland, OH, United States; Louis Stokes Cleveland VA Medical Center, Cleveland, OH, United States.
Respir Physiol Neurobiol. 2018 Apr;250:31-38. doi: 10.1016/j.resp.2018.01.015. Epub 2018 Feb 2.
We tested the functional effects of hypoglossal (CNXII) stimulation in the anesthetized rabbit before and after injections of saline into the tongue base to obstruct the airway. Data (n = 6) show little or no effect of CN XII trunk stimulation; however, medial branch stimulation (20-100 Hz; 50-500 μs pulse width, and incremental increases from 10 μA) reduced upper airway resistance. Medial branch stimulation was less effective in reducing resistance than anterior advancement of the hyoid. Endoscopic viewing (n-3) of the retropalate showed this region as the narrowest and dynamically changed by anterior hyoid displacement, with less evident effects than CNXII stimulation. We conclude that under these conditions CNXII medial branch stimulation reduces airway resistance, especially after induced obstruction.
我们在向兔舌根注射生理盐水以阻塞气道前后，测试了舌下神经（CNXII）刺激对麻醉兔的功能影响。数据（n = 6）显示，刺激CN XII主干几乎没有效果或没有效果；然而，刺激内侧支（20 - 100Hz；脉冲宽度50 - 500μs，从10μA开始递增）可降低上气道阻力。内侧支刺激在降低阻力方面不如舌骨前移有效。对软腭后区域进行内镜观察（n = 3）显示，该区域是最狭窄的，并且会随着舌骨向前移位而动态变化，但其效果不如CNXII刺激明显。我们得出结论，在这些条件下，CNXII内侧支刺激可降低气道阻力，尤其是在诱导阻塞后。
