Chopra Swati, Polotsky Vsevolod Y, Jun Jonathan C
Division of Pulmonary and Critical Care Medicine Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Am J Respir Cell Mol Biol. 2016 Mar;54(3):299-305. doi: 10.1165/rcmb.2015-0218TR.
Obstructive sleep apnea (OSA) is a common disorder that describes recurrent collapse of the upper airway during sleep. Animal models have been pivotal to the understanding of OSA pathogenesis, consequences, and treatment. In this review, we highlight the history of OSA research in animals and include the discovery of animals with spontaneous OSA, the induction of OSA in animals, and the emulation of OSA using exposures to intermittent hypoxia and sleep fragmentation.
阻塞性睡眠呼吸暂停（OSA）是一种常见的病症，其特征为睡眠期间上呼吸道反复塌陷。动物模型对于理解OSA的发病机制、后果及治疗起到了关键作用。在本综述中，我们着重介绍动物OSA研究的历史，包括自发OSA动物的发现、动物OSA的诱导以及通过间歇性低氧暴露和睡眠片段化来模拟OSA。
