Department of Neurology, Bezmialem University, Istanbul, Turkey.
Department of Neurology, Hemorrhagic Stroke Research Program, Massachusetts General Hospital, 175 Cambridge Street, Suite 300, Boston, MA, 02114, USA.
Curr Neurol Neurosci Rep. 2018 Feb 6;18(2):6. doi: 10.1007/s11910-018-0813-y.
This review aims to help neurologists managing atrial fibrillation (AF) patients who had an ischemic stroke and/or with intracranial hemorrhage (ICH) markers, therefore at high embolic/hemorrhagic risks.
Implantable loop recorders have substantially improved the accuracy of AF detection. Recent research yielded a set of powerful neuroimaging markers that can stratify ICH risk. Direct oral anticoagulants (DOAC) are easier to use with a lower ICH risk than warfarin in a general AF population. Finally, the FDA-approved left atrial appendage closure (LAAC) with the WATCHMAN device provides an option without the need for life-long anticoagulation. In this review, we introduce the concept of preventing both ischemic and hemorrhagic strokes in AF patients through accurate AF diagnosis and stratification of both embolic and ICH risks. LAAC can be considered in patients at higher hemorrhagic risks while warfarin/DOAC use should be individualized in the majority of AF patients at a low risk of bleeding.
本综述旨在帮助管理心房颤动(AF)伴缺血性卒中和/或颅内出血(ICH)标志物的患者的神经科医生,这些患者栓塞/出血风险较高。
植入式环路记录器大大提高了 AF 检测的准确性。最近的研究产生了一系列强大的神经影像学标志物,可以对 ICH 风险进行分层。与华法林相比,直接口服抗凝剂(DOAC)在一般 AF 人群中使用更方便,ICH 风险更低。最后,经美国食品药品监督管理局批准的左心耳封堵(LAAC)与 WATCHMAN 装置联合使用,为不需要终身抗凝的患者提供了一种选择。在本综述中,我们通过准确诊断 AF 和分层栓塞和 ICH 风险,介绍了预防 AF 患者发生缺血性和出血性卒的概念。对于出血风险较高的患者,可以考虑 LAAC,而对于大多数出血风险较低的 AF 患者,华法林/DOAC 的使用应个体化。