Radanovic Marcia, Facco Giuliana, Forlenza Orestes V
Laboratorio de Neurociencias (LIM-27), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Int J Geriatr Psychiatry. 2018 May;33(5):769-778. doi: 10.1002/gps.4857. Epub 2018 Feb 6.
To create a reduced and briefer version of the widely used Cambridge Cognitive Examination (CAMCog) battery as a concise cognitive test to be used in primary and secondary levels of health care to detect cognitive decline. Our aim was to reduce the administration time of the original test while maintaining its diagnostic accuracy.
On the basis of the analysis of 835 CAMCog tests performed by 429 subjects (107 controls, 192 mild cognitive impairment [MCI], and 130 dementia patients), we extracted items that most contributed to intergroup differentiation, according to 2 educational levels (≤8 and >8 y of formal schooling).
The final 33-item "low education" and 24-item"high education" CAMCog-Short correspond to 48.5% and 35% of the original version and yielded similar rates of accuracy: area under ROC curves (AUC) > 0.9 in the differentiation between controls × dementia and MCI × dementia (sensitivities > 75%; specificities > 90%); AUC > 0.7 for the differentiation between controls and MCI (sensitivities > 65%; specificities > 75%).
The CAMCog-Short emerges as a promising tool for a brief, yet sufficiently accurate, screening tool for use in clinical settings. Further prospective studies designed to validate its diagnostic accuracy are needed.
创建一个经过简化且更简短的广泛使用的剑桥认知检查（CAMCog）成套测验版本，作为一种简洁的认知测试，用于初级和二级医疗保健机构以检测认知功能衰退。我们的目标是在保持原始测试诊断准确性的同时减少其施测时间。
基于对429名受试者（107名对照者、192名轻度认知障碍[MCI]患者和130名痴呆患者）进行的835次CAMCog测试的分析，我们根据两个教育水平（≤8年和>8年正规学校教育）提取了对组间差异贡献最大的项目。
最终的33项“低教育水平”和24项“高教育水平”的CAMCog-Short版本分别相当于原始版本的48.5%和35%，并产生了相似的准确率：在区分对照者×痴呆患者和MCI×痴呆患者时，ROC曲线下面积（AUC）>0.9（敏感度>75%；特异度>90%）；在区分对照者和MCI时，AUC>0.7（敏感度>65%；特异度>75%）。
CAMCog-Short成为一种有前景的工具，可作为一种简短但足够准确的筛查工具用于临床环境。需要进一步开展前瞻性研究以验证其诊断准确性。
