Kim Soohyun, Thomasy Sara M, Ramsey David, Zhao Min, Mannis Mark J, Murphy Christopher J
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, CA, USA.
Department of Ophthalmology & Vision Science, School of Medicine, University of California Davis, Davis, CA, USA.
Vet Ophthalmol. 2018 Nov;21(6):661-667. doi: 10.1111/vop.12552. Epub 2018 Feb 6.
The course travelled by corneal epithelial cells from their stem cell niche at the limbus toward the vertex of the cornea is normally not evident due to their transparency, but in certain conditions, the epithelial cells can be rendered visible to the clinician. In such cases, the pathway taken by epithelial cells can manifest as a whorl pattern described using a variety of terms including hurricane keratitis/keratopathy, vortex keratopathy, whorl keratopathy, cornea verticillata, and at times, named after causative agents as exemplified by amiodarone keratopathy. Here, we briefly discuss the terminology used and the spectrum of conditions that can result in keratopathies with whorl patterns in human patients. We review the manifestations of such patterns in veterinary patients and discuss the state of understanding of the underlying forces that create the whorl distribution of epithelial cells on the ocular surface.
由于角膜上皮细胞的透明性，它们从角膜缘的干细胞龛向角膜顶点移动的过程通常不明显，但在某些情况下，临床医生可以看到这些上皮细胞。在这种情况下，上皮细胞所采取的路径可表现为螺旋状图案，可用多种术语描述，包括飓风性角膜炎/角膜病变、涡状角膜病变、螺旋状角膜病变、角膜涡状浑浊，有时还会以致病因素命名，如胺碘酮性角膜病变。在此，我们简要讨论所使用的术语以及可能导致人类患者出现螺旋状图案角膜病变的一系列病症。我们回顾了此类图案在兽医患者中的表现，并讨论了对导致眼表上皮细胞呈螺旋状分布的潜在力量的理解现状。
