Langford Veterinary Services, University of Bristol, Langford, Bristol, UK.
North Downs Specialist Referrals, Bletchingley, UK.
BMC Vet Res. 2019 Oct 30;15(1):384. doi: 10.1186/s12917-019-2127-y.
Pigmentary keratitis (PK) is commonly recognised in Pugs, but its aetiology is not completely understood. The aim of this study was to determine the prevalence and associated features of PK in Pugs in the United Kingdom (UK).
A total of 210 Pugs (420 eyes) were recruited from 12 UK dog shows and social events. The median age of Pugs recruited was 2.50 years (range 0.25-16.25 years). Pigmentary keratitis was detected in 369/420 (87.8%) eyes and in at least one eye 193/210 (91.9%) Pugs, of which 17/193 (8.8%) were affected unilaterally and 176/193 (91.2%) bilaterally. Pigmentary keratitis was typically mild to moderate (46.3 and 49.9% of eyes, respectively). Detection of PK was significantly associated with increased age (P = 0.002) and the presence of medial entropion of the lower eyelid (MELE) (P = 0.001). Severity of PK was significantly associated with the grade of MELE (P < 0.001). There was also a correlation between the presence of limbal pigment and PK (P = 0.036) that warrants further study.
This study estimated a high disease prevalence of PK in UK Pugs, and demonstrated significant associations with age and the presence of MELE. These associations, which have not been previously reported, offer an insight into the underlying pathophysiology of this condition in Pugs. The results encourage further population research, such as prospective longitudinal studies. These findings also support the development of clinical and breeding strategies based on the reduction of MELE and, possibly, limbal pigment.
色素性角膜炎（PK）在哈巴狗中较为常见，但病因尚不完全清楚。本研究旨在确定英国（UK）哈巴狗 PK 的患病率及相关特征。
从 12 个英国犬展和社交活动中招募了 210 只哈巴狗（420 只眼睛）。招募的哈巴狗的中位年龄为 2.50 岁（范围 0.25-16.25 岁）。在 420 只眼睛中发现 369 只（87.8%）患有色素性角膜炎，在 210 只哈巴狗中发现至少有一只眼睛患有色素性角膜炎 193 只（91.9%），其中 17 只（8.8%）为单侧发病，176 只（91.2%）为双侧发病。色素性角膜炎通常为轻度至中度（分别为 46.3%和 49.9%的眼睛）。PK 的检出与年龄增加（P=0.002）和下眼睑内翻（MELE）（P=0.001）显著相关。PK 的严重程度与 MELE 的严重程度显著相关（P<0.001）。在角膜缘色素沉着和 PK 之间也存在相关性（P=0.036），这值得进一步研究。
本研究估计英国哈巴狗 PK 的疾病患病率较高，并表明与年龄和 MELE 的存在存在显著相关性。这些以前没有报道过的相关性为哈巴狗的这种疾病的潜在病理生理学提供了一些见解。研究结果鼓励进一步开展人群研究，如前瞻性纵向研究。这些发现还支持基于减少 MELE 和可能的角膜缘色素沉着的临床和繁殖策略的发展。
