Haass M, Zamir N, Zukowska-Grojec Z
Clin Exp Hypertens A. 1986;8(2):277-87. doi: 10.3109/10641968609074776.
The effects of acute volume expansion and acute salt loading on the plasma levels of immunoreactive atrial natriuretic peptides (ir-ANP's) were investigated in conscious adult (16 weeks) Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). Basal plasma concentrations of ir-ANP's were similar (108 +/- 9 pg/ml and 105 +/- 8 pg/ml, respectively) in hypertensive and normotensive rats. In both strains mean arterial pressure, heart rate and plasma catecholamines were unaltered by acute volume expansion but significantly elevated by acute salt loading. However, both acute volume expansion and acute salt loading increased plasma concentrations of ir-ANP's similarily in SHR and WKY rats, independent of blood pressure or plasma catecholamine levels. Our findings show that chronic hypertension in SHR does not result in changes in basal or VOL- and SAL-stimulated levels of circulating ir-ANP's.
在清醒的成年（16周龄）Wistar-Kyoto（WKY）大鼠和自发性高血压大鼠（SHR）中，研究了急性容量扩张和急性盐负荷对免疫反应性心房利钠肽（ir-ANP）血浆水平的影响。高血压大鼠和正常血压大鼠的ir-ANP基础血浆浓度相似（分别为108±9 pg/ml和105±8 pg/ml）。在这两种品系中，急性容量扩张对平均动脉压、心率和血浆儿茶酚胺无影响，但急性盐负荷使其显著升高。然而，急性容量扩张和急性盐负荷均使SHR和WKY大鼠的ir-ANP血浆浓度同样升高，且与血压或血浆儿茶酚胺水平无关。我们的研究结果表明，SHR的慢性高血压不会导致循环中ir-ANP的基础水平或容量和盐刺激水平发生变化。
