Choi H Y, Takeda M
Diagn Cytopathol. 1985 Jul-Sep;1(3):241-4. doi: 10.1002/dc.2840010314.
A case of a gastric ulcer with epithelial atypia following hepatic arterial infusion chemotherapy (mitomycin C and 5-fluoro-2'-deoxyuridine) for a metastatic carcinoid tumor in the liver was observed. The gastric ulcer was endoscopically detected about 2 months after the initiation of the hepatic arterial infusion chemotherapy. The gastric epithelial atypia was severe enough to cause erroneous cytologic interpretation of the smear as a carcinoma. The cytologic and histologic appearance of chemotherapy-induced epithelial atypia is described with special emphasis on possible diagnostic pitfalls in gastric cytology.
观察到一例肝转移性类癌肿瘤接受肝动脉灌注化疗（丝裂霉素C和5-氟-2'-脱氧尿苷）后出现上皮异型性的胃溃疡病例。肝动脉灌注化疗开始约2个月后，通过内镜检查发现胃溃疡。胃上皮异型性严重到足以导致涂片的细胞学检查错误地将其诊断为癌。本文描述了化疗引起的上皮异型性的细胞学和组织学表现，并特别强调了胃细胞学中可能的诊断陷阱。
