Kwee W S, Wils J A, Schlangen J, Nuyens C M, Arends J W
Department of Pathology, St Laurentius Hospital, Roermond, The Netherlands.
Histopathology. 1994 Feb;24(2):151-4. doi: 10.1111/j.1365-2559.1994.tb01294.x.
Severe gastric lesions developed in five patients during hepatic arterial infusion chemotherapy employing 5-fluorouracil plus either leucovorin or mitomycin C. Ulceration with marked epithelial atypia was observed with striking structural distortion and cellular pleomorphism of the affected gastric mucosa. These features should be considered to be a complication of such treatment and should not be misinterpreted as malignancy.
在采用5-氟尿嘧啶加亚叶酸或丝裂霉素C进行肝动脉灌注化疗期间，有5名患者出现了严重的胃部病变。观察到溃疡伴有明显的上皮异型性，受累胃黏膜出现显著的结构扭曲和细胞多形性。这些特征应被视为这种治疗的一种并发症，不应被误诊为恶性肿瘤。
