Robinson Research Institute, University of Adelaide, Adelaide, Australia; Adelaide Medical School, University of Adelaide, Adelaide, Australia.
Robinson Research Institute, University of Adelaide, Adelaide, Australia; Waite Research Institute & School of Agriculture, Food and Wine, University of Adelaide, Adelaide, Australia.
J Trace Elem Med Biol. 2018 Mar;46:103-109. doi: 10.1016/j.jtemb.2017.11.016. Epub 2017 Dec 5.
Maternal micronutrient deficiencies in pregnancy can have profound effects on fetal development and pregnancy outcome. Plasma trace minerals including copper, zinc, selenium and iron have been shown to be extremely important in supporting reproduction. We sought to determine whether there is an association between maternal trace mineral status in early pregnancy and pregnancy complications using a prospective cohort study of 1065 pregnant Australian women who were recruited as part of the Screening for Pregnancy Endpoints (SCOPE) study in Adelaide. Copper, zinc, selenium and iron present in the plasma were measured using mass spectrometry in samples collected at 15±1 weeks' gestation. After adjusting for covariates, women with lower plasma copper (<27.9μmol/L and 27.9-32.5μmol/L) had decreased risk for any pregnancy complication when compared with women with high plasma copper (>32.5μmol/L) (aRR=0.87; 95% CI=0.76, 0.99 and aRR=0.88; 95% CI=0.78, 1.00, respectively). This was also observed when adjusting for plasma zinc and selenium status (<27.9μmol/L: aRR=0.81; 95% CI=0.69, 0.96 and 27.9-32.5μmol/L: aRR=0.84; 95% CI=0.72, 0.98). Combined low copper and zinc status was also associated with a reduced risk of any pregnancy complication as compared with high copper and zinc status (aRR=0.80; 95% CI=0.70, 0.93). These results provide justification for further work into elucidating the mechanistic role of trace elements in early pregnancy, as well as their interactions in supporting successful pregnancy outcomes.
孕妇在妊娠期间的微量营养素缺乏可能对胎儿发育和妊娠结局产生深远影响。血浆微量元素，包括铜、锌、硒和铁，在支持生殖方面被证明是极其重要的。我们试图通过对 1065 名澳大利亚孕妇进行前瞻性队列研究来确定妊娠早期母体微量元素状况与妊娠并发症之间是否存在关联，这些孕妇是阿德莱德 Screening for Pregnancy Endpoints（SCOPE）研究的一部分。在妊娠 15±1 周时采集的样本中，使用质谱法测量血浆中的铜、锌、硒和铁。在调整了协变量后，与高血浆铜 (>32.5μmol/L)相比，血浆铜水平较低(<27.9μmol/L 和 27.9-32.5μmol/L)的女性发生任何妊娠并发症的风险降低(aRR=0.87；95%CI=0.76，0.99 和 aRR=0.88；95%CI=0.78，1.00)。当调整血浆锌和硒状况时也观察到了这种情况(<27.9μmol/L：aRR=0.81；95%CI=0.69，0.96 和 27.9-32.5μmol/L：aRR=0.84；95%CI=0.72，0.98)。与高铜和高锌状态相比，铜和锌联合低状态也与降低任何妊娠并发症的风险相关(aRR=0.80；95%CI=0.70，0.93)。这些结果为进一步阐明微量营养素在妊娠早期的作用机制以及它们在支持成功妊娠结局中的相互作用提供了依据。
