儿童和青少年时期的铜/锌比值：综述
Copper/Zinc Ratio in Childhood and Adolescence: A Review.
作者信息
Escobedo-Monge Marlene Fabiola, Barrado Enrique, Parodi-Román Joaquín, Escobedo-Monge María Antonieta, Torres-Hinojal María Carmen, Marugán-Miguelsanz José Manuel
机构信息
Faculty of Medicine, University of Valladolid, Avenida Ramón y Cajal, 7, 47005 Valladolid, Spain.
Department of Analytical Chemistry, Science Faculty, Campus Miguel Delibes, University of Valladolid, Calle Paseo de Belén, 7, 47011 Valladolid, Spain.
出版信息
Metabolites. 2023 Jan 3;13(1):82. doi: 10.3390/metabo13010082.
Both copper (Cu) and zinc (Zn) are crucial micronutrients for human growth and development. This literature review covered the last five years of available evidence on the Cu/Zn ratio in children and adolescents. We searched PubMed, Web of Science, Google Scholar, Cochrane Library, and Science Direct for publications between 2017 and 2022, especially in English, although publications in other languages with abstracts in English were included. The main terms used were "copper", "zinc", "copper-zinc", and "zinc-copper" ratios. Cu and Zn determinations made in blood, plasma, or serum were included. This review comprises several cross-sectional and case-control studies with substantial results. The bibliographic search generated a compilation of 19 articles, in which 63.2% of the studies mostly reported a significantly higher Cu/Zn ratio, and 57.9% of them informed significantly lower levels of Zn. We conclude that children and adolescents with acute and chronic conditions are at greater risk of developing elevated Cu/Zn ratios, related to altered nutritional, infectious, and inflammatory status.
铜（Cu）和锌（Zn）都是人类生长发育所必需的微量营养素。这篇文献综述涵盖了过去五年中有关儿童和青少年铜锌比的现有证据。我们在PubMed、科学网、谷歌学术、考克兰图书馆和科学Direct上搜索了2017年至2022年间的出版物，尤其是英文出版物，不过也包括有英文摘要的其他语言出版物。使用的主要检索词是“铜”“锌”“铜锌”和“锌铜”比。包括在血液、血浆或血清中进行的铜和锌测定。这篇综述包含了几项有实质性结果的横断面研究和病例对照研究。文献检索共收集到19篇文章，其中63.2%的研究大多报告铜锌比显著升高，57.9%的研究表明锌水平显著降低。我们得出结论，患有急性和慢性疾病的儿童和青少年出现铜锌比升高的风险更大，这与营养、感染和炎症状态的改变有关。
Zotero 插件