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心房利钠因子抑制离体灌注大鼠肠系膜动脉中交感神经刺激所诱发的去甲肾上腺素释放。

Atrial natriuretic factor inhibits norepinephrine release evoked by sympathetic nerve stimulation in isolated perfused rat mesenteric arteries.

作者信息

Nakamaru M, Inagami T

出版信息

Eur J Pharmacol. 1986 Apr 29;123(3):459-61. doi: 10.1016/0014-2999(86)90724-7.

DOI:10.1016/0014-2999(86)90724-7
PMID:2941312
Abstract

The effect of atrial natriuretic factor (ANF) on [3H]norepinephrine release evoked by sympathetic nerve stimulation was examined in the isolated perfused rat mesenteric arteries. ANF (1 nM to 0.1 microM) caused a dose-dependent inhibition of [3H]norepinephrine release during nerve stimulation. The present result indicates that ANF inhibits noradrenergic neurotransmission in the rat mesenteric arteries through a prejunctional mechanism. This prejunctional effect of ANF may in part contribute to its vasodilation action.

摘要

在离体灌注的大鼠肠系膜动脉中，研究了心房利钠因子（ANF）对交感神经刺激诱发的[3H]去甲肾上腺素释放的影响。ANF（1 nM至0.1 microM）在神经刺激期间引起[3H]去甲肾上腺素释放的剂量依赖性抑制。目前的结果表明，ANF通过节前机制抑制大鼠肠系膜动脉中的去甲肾上腺素能神经传递。ANF的这种节前效应可能部分有助于其血管舒张作用。

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Atrial natriuretic factor inhibits norepinephrine release evoked by sympathetic nerve stimulation in isolated perfused rat mesenteric arteries.心房利钠因子抑制离体灌注大鼠肠系膜动脉中交感神经刺激所诱发的去甲肾上腺素释放。
Eur J Pharmacol. 1986 Apr 29;123(3):459-61. doi: 10.1016/0014-2999(86)90724-7.
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