Kubo T, Su C
Eur J Pharmacol. 1983 Feb 18;87(2-3):349-52. doi: 10.1016/0014-2999(83)90352-7.
Adenosine (10-30 microM) inhibited the 3H-efflux evoked by sympathetic nerve stimulation in the perfused rat mesenteric arteries preincubated with [3H]norepinephrine. The inhibition was smaller in the prehypertensive (5 weeks old) as well as hypertensive (15-18 weeks) SHR (spontaneously hypertensive rats), compared with age-matched normotensive Wistar Kyoto rats. However, it was not diminished in Wistar rats rendered hypertensive by left renal artery occlusion. Thus, a diminished adenosine-mediated presynaptic inhibition of adrenergic transmission appears to be genetically inherent in SHR.
腺苷（10 - 30微摩尔）抑制了在预先用[3H]去甲肾上腺素预孵育的灌注大鼠肠系膜动脉中交感神经刺激所诱发的3H外流。与年龄匹配的正常血压Wistar Kyoto大鼠相比，高血压前期（5周龄）以及高血压期（15 - 18周）的自发性高血压大鼠（SHR）中的这种抑制作用较小。然而，在通过左肾动脉闭塞导致高血压的Wistar大鼠中，这种抑制作用并未减弱。因此，腺苷介导的肾上腺素能传递的突触前抑制减弱似乎在SHR中是遗传固有的。
